<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Aims:</bold> The present study aims to investigate the association between catecholamine metabolites (normetanephrine [NMN] and metanephrine [MN]) and polycystic ovarian syndrome (PCOS) and its clinical manifestations.
<bold>Materials and methods:</bold> A total of 60 female patients (18-37 years) were included in the study. Twenty-five healthy women and 35 patients with PCOS provided blood and urine samples. Anthropometric, biochemical, and hormonal parameters, e.g. immunoreactive insulin, total testosterone, gonadotropins, and dehydroepiandrosterone-sulfate (DHEAS) have been investigated. Twenty-four-hour urinary metanephrines (MN and NMN) were measured by radioimmunoassay technique.
<bold>Results:</bold> MN and NMN showed a strong positive correlation (r = +0.645, p &lt; 0.001) in women with PCOS, but nephrines were not significantly associated with the hormonal, anthropometric, and metabolic parameters of the patients (p > 0.05 for all). No differences in urinary nephrines concentrations between women with PCOS and healthy individuals after adjustment for age and BMI were established. However, lower 24-hour urinary MN levels predicted the development of menstrual irregularity after adjustment for age and BMI (OR = 1,015 [95% CI 1,001-1,029], p = 0,036).
<bold>Conclusions:</bold> Adrenomedullary dysfunction might influence the development of chronic anovulation in young women.
</abstract>

Aims: The present study aims to investigate the association between catecholamine metabolites (normetanephrine [NMN] and metanephrine [MN]) and polycystic ovarian syndrome (PCOS) and its clinical manifestations.
Materials and methods: A total of 60 female patients (18-37 years) were included in the study. Twenty-five healthy women and 35 patients with PCOS provided blood and urine samples. Anthropometric, biochemical, and hormonal parameters, e.g. immunoreactive insulin, total testosterone, gonadotropins, and dehydroepiandrosterone-sulfate (DHEAS) have been investigated. Twenty-four-hour urinary metanephrines (MN and NMN) were measured by radioimmunoassay technique.
Results: MN and NMN showed a strong positive correlation (r = +0.645, p < 0.001) in women with PCOS, but nephrines were not significantly associated with the hormonal, anthropometric, and metabolic parameters of the patients (p > 0.05 for all). No differences in urinary nephrines concentrations between women with PCOS and healthy individuals after adjustment for age and BMI were established. However, lower 24-hour urinary MN levels predicted the development of menstrual irregularity after adjustment for age and BMI (OR = 1,015 [95% CI 1,001-1,029], p = 0,036).
Conclusions: Adrenomedullary dysfunction might influence the development of chronic anovulation in young women.

Metanephrine and Normetanephrine Urine Excretion in Patients with PCOS

Department of Endocrinology, Medical Faculty

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Metanephrine and Normetanephrine Urine Excretion in Patients with PCOS"}

Aims: The present study aims to investigate the association between catecholamine metabolites (normetanephrine [NMN] and metanephrine [MN]) and polycystic ovarian syndrome (PCOS) and its clinical manifestations.
Materials and methods: A total of 60 female patients (18-37 years) were included in the study. Twenty-five healthy women and 35 patients with PCOS provided blood and urine samples. Anthropometric, biochemical, and hormonal parameters, e.g. immunoreactive insulin, total testosterone, gonadotropins, and dehydroepiandrosterone-sulfate (DHEAS) have been investigated. Twenty-four-hour urinary metanephrines (MN and NMN) were measured by radioimmunoassay technique.
Results: MN and NMN showed a strong positive correlation (r = +0.645, p  0.05 for all). No differences in urinary nephrines concentrations between women with PCOS and healthy individuals after adjustment for age and BMI were established. However, lower 24-hour urinary MN levels predicted the development of menstrual irregularity after adjustment for age and BMI (OR = 1,015 [95% CI 1,001-1,029], p = 0,036).
Conclusions: Adrenomedullary dysfunction might influence the development of chronic anovulation in young women.

Aims: The present study aims to investigate the association between catecholamine metabolites (normetanephrine [NMN] and metanephrine [MN]) and polycystic...

Metanephrine and Normetanephrine Urine Excretion in Patients with PCOS

Published Online: Jul 11, 2022

Page range: 5 - 10

Received: May 03, 2022

Accepted: May 17, 2022

DOI: https://doi.org/10.2478/amb-2022-0012

Keywords
normetanephrine, metanephrine, polycystic ovarian syndrome

© 2022 R. Robeva et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Metanephrine and Normetanephrine Urine Excretion in Patients with PCOS

Published Online: Jul 11, 2022

Page range: 5 - 10

Received: May 03, 2022

Accepted: May 17, 2022

DOI: https://doi.org/10.2478/amb-2022-0012

Keywordsnormetanephrine, metanephrine, polycystic ovarian syndrome

© 2022 R. Robeva et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
normetanephrine, metanephrine, polycystic ovarian syndrome