<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Esophageal carcinoma is an extremely aggressive cancer with an early distant spread, high rate of local recurrence, and low overall survival. Herewith we present 3 patients with advanced moderately and low differentiated adenocarcinomas, who underwent neoadjuvant chemotherapy (nCT) (two patients) and combined nCT with neoadjuvant radiation therapy (nRT) (one patient), followed by radical surgery. Subtotal esophageal resection, proximal gastric resection, and intrathoracic right gastroesophagoplasty a modo Ivor-Lewis were performed in the first two patients, while total gastrectomy, distal third esophageal resection, splenectomy and left intrathoracic esophagojejunoplasty a modo Roux were performed in the third one. A literature review of the role of neoadjuvant chemoradiotherapy (nCRT) as part of a trimodality therapy for advanced esophageal carcinoma is presented.</p>
</abstract>

Esophageal carcinoma is an extremely aggressive cancer with an early distant spread, high rate of local recurrence, and low overall survival. Herewith we present 3 patients with advanced moderately and low differentiated adenocarcinomas, who underwent neoadjuvant chemotherapy (nCT) (two patients) and combined nCT with neoadjuvant radiation therapy (nRT) (one patient), followed by radical surgery. Subtotal esophageal resection, proximal gastric resection, and intrathoracic right gastroesophagoplasty a modo Ivor-Lewis were performed in the first two patients, while total gastrectomy, distal third esophageal resection, splenectomy and left intrathoracic esophagojejunoplasty a modo Roux were performed in the third one. A literature review of the role of neoadjuvant chemoradiotherapy (nCRT) as part of a trimodality therapy for advanced esophageal carcinoma is presented.

Surgical Treatment of Patients with Adenocarcinoma of the Distal Esophageal Portion and Gastroesophageal Junction Performed After Neoadjuvant Chemotherapy and Combined Chemoradiation

University Hospital “Sv. Sofia”, Faculty of Medicine, Medical University – Sofia

University Hospital “Ts. Yoanna”, Faculty of Medicine, Medical University – Sofia

University Hospital “Sv. Ivan Rilski”, Faculty of Medicine, Medical University – Sofia

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Esophageal carcinoma is an extremely aggressive cancer with an early distant spread, high rate of local recurrence, and low overall survival. Herewith we...

Surgical Treatment of Patients with Adenocarcinoma of the Distal Esophageal Portion and Gastroesophageal Junction Performed After Neoadjuvant Chemotherapy and Combined Chemoradiation

Published Online: Apr 22, 2022

Page range: 40 - 45

Received: Dec 28, 2021

Accepted: Jan 04, 2022

DOI: https://doi.org/10.2478/amb-2022-0007

Keywords
adenocarcinoma, esophageal carcinoma, neoadjuvant therapy, gastrectomy, gastroesophagoplasty, esophagojejunoplasty

© 2022 G. Yankov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Surgical Treatment of Patients with Adenocarcinoma of the Distal Esophageal Portion and Gastroesophageal Junction Performed After Neoadjuvant Chemotherapy and Combined Chemoradiation

Published Online: Apr 22, 2022

Page range: 40 - 45

Received: Dec 28, 2021

Accepted: Jan 04, 2022

DOI: https://doi.org/10.2478/amb-2022-0007

Keywordsadenocarcinoma, esophageal carcinoma, neoadjuvant therapy, gastrectomy, gastroesophagoplasty, esophagojejunoplasty

© 2022 G. Yankov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
adenocarcinoma, esophageal carcinoma, neoadjuvant therapy, gastrectomy, gastroesophagoplasty, esophagojejunoplasty