<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Male infertility is caused by spermatogenetic failure, clinically noted as oligoor azoospermia. Approximately 20% of infertile patients carry a genetic defect. The most frequent genetic defect leading to azoospermia (or severe oligozoospermia) is Klinefelter syndrome (47, XXY), which is numerical chromosomal abnormality and Y- structural chromosome aberration. The human X chromosome is the most stable of all human chromosomes. The X chromosome is loaded with regions of acquired, rapidly evolving genes. The X chromosome may actually play an essential role in male infertility and sperm production. Here we will describe X chromosome aberrations, which are associated with male infertility.</p>
</abstract>

Male infertility is caused by spermatogenetic failure, clinically noted as oligoor azoospermia. Approximately 20% of infertile patients carry a genetic defect. The most frequent genetic defect leading to azoospermia (or severe oligozoospermia) is Klinefelter syndrome (47, XXY), which is numerical chromosomal abnormality and Y- structural chromosome aberration. The human X chromosome is the most stable of all human chromosomes. The X chromosome is loaded with regions of acquired, rapidly evolving genes. The X chromosome may actually play an essential role in male infertility and sperm production. Here we will describe X chromosome aberrations, which are associated with male infertility.

Association of X Chromosome Aberrations with Male Infertility

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Association of X Chromosome Aberrations with Male Infertility"}

Male infertility is caused by spermatogenetic failure, clinically noted as oligoor azoospermia. Approximately 20% of infertile patients carry a genetic defect....

Association of X Chromosome Aberrations with Male Infertility

Published Online: Nov 20, 2021

Page range: 69 - 72

Received: Aug 11, 2020

Accepted: Sep 22, 2020

DOI: https://doi.org/10.2478/amb-2021-0051

Keywords
Klinefelter syndrome, azoospermia, chromosome aberration, androgen receptors, Y chromosome, X chromosome

© 2021 S. Xharra et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Association of X Chromosome Aberrations with Male Infertility

Published Online: Nov 20, 2021

Page range: 69 - 72

Received: Aug 11, 2020

Accepted: Sep 22, 2020

DOI: https://doi.org/10.2478/amb-2021-0051

KeywordsKlinefelter syndrome, azoospermia, chromosome aberration, androgen receptors, Y chromosome, X chromosome

© 2021 S. Xharra et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Klinefelter syndrome, azoospermia, chromosome aberration, androgen receptors, Y chromosome, X chromosome