<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The COVID-19 pandemic caused by the SARS-CoV-2 has increased the burden on healthcare system. Despite some progress in its diagnostics has been made, effective prevention and treatment are still insufficient. Since SARS-CoV-2 infections often cause systemic inflammation and multiple organ failure, the therapeutic options aimed at modulating the host immune responses to prevent subsequent systemic complications are demanding. The review provides a summary of the SARS-CoV-2 virus infection and underlines the current perception of pulmonary host’s immune response and its contributions to disease severity and systemic inflammation. Signaling pathways which have the potential to manipulate host immunity and improve clinical outcomes are also presented.</p>
</abstract>

The COVID-19 pandemic caused by the SARS-CoV-2 has increased the burden on healthcare system. Despite some progress in its diagnostics has been made, effective prevention and treatment are still insufficient. Since SARS-CoV-2 infections often cause systemic inflammation and multiple organ failure, the therapeutic options aimed at modulating the host immune responses to prevent subsequent systemic complications are demanding. The review provides a summary of the SARS-CoV-2 virus infection and underlines the current perception of pulmonary host’s immune response and its contributions to disease severity and systemic inflammation. Signaling pathways which have the potential to manipulate host immunity and improve clinical outcomes are also presented.

Infection, Inflammation and Immunity in Covid-19 Infection

University Hospital for Respiratory Diseases “Sv. Sophia“ – Sofia

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Infection, Inflammation and Immunity in Covid-19 Infection"}

The COVID-19 pandemic caused by the SARS-CoV-2 has increased the burden on healthcare system. Despite some progress in its diagnostics has been made, effective...

Infection, Inflammation and Immunity in Covid-19 Infection

Published Online: Oct 22, 2021

Page range: 77 - 82

Received: Feb 03, 2021

Accepted: Mar 27, 2021

DOI: https://doi.org/10.2478/amb-2021-0040

Keywords
SARS-CoV-2 virus, immune responses, systemic inflammation, signaling pathways

© 2021 R. Cherneva et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Infection, Inflammation and Immunity in Covid-19 Infection

Published Online: Oct 22, 2021

Page range: 77 - 82

Received: Feb 03, 2021

Accepted: Mar 27, 2021

DOI: https://doi.org/10.2478/amb-2021-0040

KeywordsSARS-CoV-2 virus, immune responses, systemic inflammation, signaling pathways

© 2021 R. Cherneva et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
SARS-CoV-2 virus, immune responses, systemic inflammation, signaling pathways