<abstract xmlns="http://www.w3.org/1999/xhtml"><p>We present a case of a 29-year-old Bulgarian woman with autoimmune thyroiditis and recurrent angioedema. The patient presented with a one-year-long history of recurrent angioedema and Hashimoto’s thyroiditis. Physical examination showed oedema surrounded by erythema on the forearms, and erythematous, itchy plaques spreading over her face, neck, chest, abdomen, and extremities. Blood tests showed elevated total immunoglobulin E (IgE). The patient had been diagnosed with Hashimoto’s thyroiditis and hypothyroidism. She had been taking levothyroxine 50 μg/d, resulting in a good hormonal control; however, her anti-thyroid peroxidase (anti-TPO) antibodies were high. She was started on methylprednisolone and antihistamines. In three weeks, we observed a good therapeutic response to the treatment and the lesions remitted. IgE dropped within normal range. Levels of anti-TPO antibodies were persistently high. In conclusion, patients with angioedema should be tested for thyroid autoimmunity. Further delve into the pathogenesis of angioedema in them is warranted in order to explore the possibility of an underlying atopy in those not responding to the standard treatment with levothyroxine.</p></abstract>

We present a case of a 29-year-old Bulgarian woman with autoimmune thyroiditis and recurrent angioedema. The patient presented with a one-year-long history of recurrent angioedema and Hashimoto’s thyroiditis. Physical examination showed oedema surrounded by erythema on the forearms, and erythematous, itchy plaques spreading over her face, neck, chest, abdomen, and extremities. Blood tests showed elevated total immunoglobulin E (IgE). The patient had been diagnosed with Hashimoto’s thyroiditis and hypothyroidism. She had been taking levothyroxine 50 μg/d, resulting in a good hormonal control; however, her anti-thyroid peroxidase (anti-TPO) antibodies were high. She was started on methylprednisolone and antihistamines. In three weeks, we observed a good therapeutic response to the treatment and the lesions remitted. IgE dropped within normal range. Levels of anti-TPO antibodies were persistently high. In conclusion, patients with angioedema should be tested for thyroid autoimmunity. Further delve into the pathogenesis of angioedema in them is warranted in order to explore the possibility of an underlying atopy in those not responding to the standard treatment with levothyroxine.

Angioedema in a Patient with Autoimmune Thyroiditis – A Case Report

2nd Department of Internal Medicine, Faculty of Medicine

Department of Hygiene and Ecomedicine, Faculty of Public Health

Department of Microbiology and Immunology, Faculty of Pharmacy

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Angioedema in a Patient with Autoimmune Thyroiditis \u2013 A Case Report"}

We present a case of a 29-year-old Bulgarian woman with autoimmune thyroiditis and recurrent angioedema. The patient presented with a one-year-long history of...

Angioedema in a Patient with Autoimmune Thyroiditis – A Case Report

Published Online: Jul 27, 2020

Page range: 34 - 37

Accepted: Dec 01, 2019

DOI: https://doi.org/10.2478/amb-2020-0021

Keywords
angioedema, Hashimoto’s thyroiditis, urticariа

© 2020 S. Dermendzhiev et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Angioedema in a Patient with Autoimmune Thyroiditis – A Case Report

Published Online: Jul 27, 2020

Page range: 34 - 37

Accepted: Dec 01, 2019

DOI: https://doi.org/10.2478/amb-2020-0021

Keywordsangioedema, Hashimoto’s thyroiditis, urticariа

© 2020 S. Dermendzhiev et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
angioedema, Hashimoto’s thyroiditis, urticariа