<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The process of neoangiogenesis is one of the classic hallmarks of a cancer. Its intricate mechanisms have long been one of the major domains in cancer research and a hope for a therapeutic breakthrough. Last decade a new subgroup of non-coding RNA molecules was reported called microRNAs. Literally hundreds of new molecules in this class are being uncovered as pivotal regulators in virtually all intracellular processes. The aim of this study is to classify and review those microRNA molecules that have a role in the processes of tumor angiogenesis and map their places in the regulatory framework of the classical proangiogenic genes and their canonical cascades.</p></abstract>

The process of neoangiogenesis is one of the classic hallmarks of a cancer. Its intricate mechanisms have long been one of the major domains in cancer research and a hope for a therapeutic breakthrough. Last decade a new subgroup of non-coding RNA molecules was reported called microRNAs. Literally hundreds of new molecules in this class are being uncovered as pivotal regulators in virtually all intracellular processes. The aim of this study is to classify and review those microRNA molecules that have a role in the processes of tumor angiogenesis and map their places in the regulatory framework of the classical proangiogenic genes and their canonical cascades.

Regulatory Role of microRNAs in Tumor Angiogenesis

Department of Medical Chemistry and Biochemistry and Molecular Medicine Center

Department of Anesthesiology & Intensive Care

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Regulatory Role of microRNAs in Tumor Angiogenesis"}

The process of neoangiogenesis is one of the classic hallmarks of a cancer. Its intricate mechanisms have long been one of the major domains in cancer research...

Regulatory Role of microRNAs in Tumor Angiogenesis

Published Online: May 21, 2020

Page range: 67 - 72

Received: May 01, 2019

Accepted: Jun 01, 2019

DOI: https://doi.org/10.2478/amb-2020-0012

Keywords
tumor angiogenesis, microRNA, VEGF-A, HIF, HIF switch

© 2018 T. Popov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Regulatory Role of microRNAs in Tumor Angiogenesis

Published Online: May 21, 2020

Page range: 67 - 72

Received: May 01, 2019

Accepted: Jun 01, 2019

DOI: https://doi.org/10.2478/amb-2020-0012

Keywordstumor angiogenesis, microRNA, VEGF-A, HIF, HIF switch

© 2018 T. Popov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
tumor angiogenesis, microRNA, VEGF-A, HIF, HIF switch