<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Cocaine is a natural alkaloid extracted from the leaves of the South American plant Erythroxylum coca or synthesized chemically. After cannabis, it is the second most frequently abused recreational substance worldwide. Cocaine can affect every tissue and organ within the human body, including the kidneys, causing tissue ischemia due to vasoconstriction, endothelial dysfunction and damage, procoagulant activity and oxidative stress with subsequent ischemic infarctions and fibrosis. The renal changes in cocaine abuse and addiction are due to rhabdomyolysis, ischemic, hypertensive, and inflammatory changes with the development of cell proliferation and fibrosis. The authors present three patients with cocaine-associated renal damage and discuss the underlying mechanisms of cocaine-induces tissue changes.</p></abstract>

Cocaine is a natural alkaloid extracted from the leaves of the South American plant Erythroxylum coca or synthesized chemically. After cannabis, it is the second most frequently abused recreational substance worldwide. Cocaine can affect every tissue and organ within the human body, including the kidneys, causing tissue ischemia due to vasoconstriction, endothelial dysfunction and damage, procoagulant activity and oxidative stress with subsequent ischemic infarctions and fibrosis. The renal changes in cocaine abuse and addiction are due to rhabdomyolysis, ischemic, hypertensive, and inflammatory changes with the development of cell proliferation and fibrosis. The authors present three patients with cocaine-associated renal damage and discuss the underlying mechanisms of cocaine-induces tissue changes.

Renal Changes in Cocaine Abuse and Addiction

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Renal Changes in Cocaine Abuse and Addiction"}

Cocaine is a natural alkaloid extracted from the leaves of the South American plant Erythroxylum coca or synthesized chemically. After cannabis, it is the...

Renal Changes in Cocaine Abuse and Addiction

Published Online: May 31, 2019

Page range: 57 - 61

DOI: https://doi.org/10.2478/amb-2019-0020

Keywords
cocaine, systemic effects, renal damage, rhabdomyolysis, ischemia, hypertension, coagulation, cholesterol

© 2019 M. Nikolova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Renal Changes in Cocaine Abuse and Addiction

Published Online: May 31, 2019

Page range: 57 - 61

DOI: https://doi.org/10.2478/amb-2019-0020

Keywordscocaine, systemic effects, renal damage, rhabdomyolysis, ischemia, hypertension, coagulation, cholesterol

© 2019 M. Nikolova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
cocaine, systemic effects, renal damage, rhabdomyolysis, ischemia, hypertension, coagulation, cholesterol