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Antioxidative, cytotoxic, and antibacterial properties of self-assembled glycine-histidine-based dipeptides with or without silver nanoparticles in bio-inspired film

Merve Eylul Kiymaci
Merve Eylul Kiymaci
, 
Hakan Erdoğan
Hakan Erdoğan
 and 
Merve Bacanlı
Merve Bacanlı
   | Jul 07, 2022
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Article Category: Original article
Published Online: Jul 07, 2022
Page range: 169 - 177
Received: Apr 01, 2022
Accepted: Jun 01, 2022
DOI: https://doi.org/10.2478/aiht-2022-73-3658
© 2022 Merve Eylul Kiymaci, Hakan Erdoğan, and Merve Bacanlı, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

SEM image of self-assembled Gly-His dipeptide films in various solvents: a) 1,1,1,3,3,3-hexafluoro-2-propanol, b) water, c) ethanol, d) acetone, e) chloroform, and f) tetrahydrofuran
SEM image of self-assembled Gly-His dipeptide films in various solvents: a) 1,1,1,3,3,3-hexafluoro-2-propanol, b) water, c) ethanol, d) acetone, e) chloroform, and f) tetrahydrofuran

Figure 2

FTIR spectra of Gly-His dipeptide films self-assembled in various solvent media. HFIP – 1,1,1,3,3,3-hexafluoro-2-propanol; THF – tetrahydrofuran
FTIR spectra of Gly-His dipeptide films self-assembled in various solvent media. HFIP – 1,1,1,3,3,3-hexafluoro-2-propanol; THF – tetrahydrofuran

Figure 3

SEM images of (a) morphological changes in Gly-His films formed in AgNO3 solutions for 6 h and (b) zoomed AgNP-decorated Gly-His structure with the EDX spectrum
SEM images of (a) morphological changes in Gly-His films formed in AgNO3 solutions for 6 h and (b) zoomed AgNP-decorated Gly-His structure with the EDX spectrum

Figure 4

SEM images of Gly-His film structures kept in AgNO3 solution for a) 0 h, b) 3 h, c) 6 h, d) 12 h, and e) 24 h
SEM images of Gly-His film structures kept in AgNO3 solution for a) 0 h, b) 3 h, c) 6 h, d) 12 h, and e) 24 h

Figure 5

FTIR spectra of Gly-His dipeptide films with and without Ag
FTIR spectra of Gly-His dipeptide films with and without Ag

Figure 6

XRD spectra of Gly-His film alone or kept in AgNO3 solution for various times
XRD spectra of Gly-His film alone or kept in AgNO3 solution for various times

Figure 7

Antioxidant activity of Gly-His films alone and those coated with AgNPs
Antioxidant activity of Gly-His films alone and those coated with AgNPs

Figure 8

Cytotoxic effects of Gly-His dipeptide with and without AgNPs in L929 cells
Cytotoxic effects of Gly-His dipeptide with and without AgNPs in L929 cells

Figure 9

Antibacterial activity of Gly-His dipeptides with or without AgNPs against a) Escherichia coli, b) Staphylococcus aureus, and c) Pseudomonas aeruginosa
Antibacterial activity of Gly-His dipeptides with or without AgNPs against a) Escherichia coli, b) Staphylococcus aureus, and c) Pseudomonas aeruginosa
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Journal Subjects:
Medicine, Basic Medical Science, other
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