Associations of NLRP3 and CARD8 gene polymorphisms with alcohol dependence and commonly related psychiatric disorders: a preliminary study
, and | Sep 28, 2021
About this article
Article Category: Original article
Published Online: Sep 28, 2021
Page range: 191 - 197
Received: May 01, 2020
Accepted: Sep 01, 2021
DOI: https://doi.org/10.2478/aiht-2021-72-3432
© 2021 Anja Plemenitaš Ilješ, Blanka Kores Plesničar, and Vita Dolžan, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Associations between NLPR3 rs35829419 genotypes and alcohol-related mental disorders
| Mental disorders | Hospitalised alcohol-dependent patients | Abstinent alcohol-dependent participants | Controls | ||||
|---|---|---|---|---|---|---|---|
| Mean score±SD | p-value | Mean score±SD | p-value | Mean score±SD | p-value | ||
| CC | 4.2±4.6 | 0.742 | 1.8±2.2 | 0.661 | 1.7±1.5 | 0.498 | |
| AC | 3.6±4.4 | 1.3±2.5 | 1.0±0.0 | ||||
| AA | 1.0 | 1.0 | 1.0 | ||||
| CC | 2.9±3.1 | 0.787 | 1.4±1.8 | 0.810 | 1.3±0.9 | 0.644 | |
| AC | 3.2±3.3 | 1.1±0.3 | 1.0±0.0 | ||||
| AA | 1.0 | 1.0 | 1.0 | ||||
| CC | 12.9±11.0 | 0.555 | 12.1±10.1 | 0.353 | 10.5±7.2 | 0.615 | |
| AC | 8.8±10.9 | 16.5±11.1 | 8.7±1.3 | ||||
| AA | 10.0 | 18.0 | 5.0 | ||||
| CC | 18.9±11.1 | 0.681 | 3.2±2.3 | 0.757 | 3.5±1.7 | 0.926 | |
| AC | 15.8±13.2 | 3.7±3.3 | 3.3±0.8 | ||||
| AA | 14.0 | 3.0 | 4.0 | ||||
| Depression (Zung) | CC | 35.9±11.0 | 0.881 | 31.1±7.4 | 0.653 | 23.0±3.8 | 0.311 |
| AC | 34.9±11.5 | 29.3±6.1 | 21.8±2.4 | ||||
| AA | 31.0 | 27.0 | 28.0 | ||||
| CC | 34.9±8.4 | 0.535 | 30.1±6.9 | 0.886 | 22.6±3.1 | 0.742 | |
| AC | 31.9±7.1 | 31.1±5.6 | 22.7±3.4 | ||||
| AA | 31.0 | 29.0 | 25.0 | ||||
| CC | 24.3±10.8 | 0.853 | 20.5±10.3 | 0.735 | 14.8±8.8 | 0.220 | |
| AC | 26.0±7.2 | 19.6±7.4 | 10.2±4.1 | ||||
| AA | 21.0 | 13.0 | 25.0 | ||||
| CC | 23.0±6.8 | 0.069 | |||||
| AC | 28.4±4.0 | ||||||
| AA | 23.0 | ||||||
Socio-demographic characteristics of study participants
| Characteristics | Hospitalised alcohol- dependent patients (n=88) | Abstinent alcohol-dependent participants (n=99) | Controls (n=94) | p-value |
|---|---|---|---|---|
| Age (years) | 45.8±10.0 | 49.1±8.1 | 34.4±11.7 | 0.003 |
| Education (years) | 11.3±2.2 | 11.7±2.4 | 12.7±1.9 | 0.001 |
| Single | 38 (43 %) | 22 (22 %) | 24 (25 %) | 0.004 |
| In partnership | 50 (56 %) | 77 (78 %) | 70 (75 %) | |
| Rural residents | 45 (51 %) | 48 (48 %) | 36 (38 %) | 0.293 |
| Urban residents | 43 (49 %) | 51 (52 %) | 58 (62 %) |
NLPR3 rs35829419 and CARD8 rs2043211 genotype distribution by groups
| Genotypes | Hospitalised alcohol-dependent patients (n=88) | Abstinent alcohol- dependent participants (n=99) | Controls (n=94) | p-value1 | Merged alcohol- dependents (n=185) | p-value2 |
|---|---|---|---|---|---|---|
| 0.838 | 0.500 | |||||
| CC | 78 (88 %) | 87 (88 %) | 87 (93 %) | 165 (88 %) | ||
| AC | 9 (11 %) | 11 (11 %) | 6 (6 %) | 20 (11 %) | ||
| AA | 1 (1 %) | 1 (1 %) | 1 (1 %) | 2 (1 %) | ||
| 0.055 | ||||||
| AA | 34 (39 %) | 52 (53 %) | 45 (48 %) | 86 (46 %) | ||
| AT | 44 (51 %) | 42 (42 %) | 34 (36 %) | 86 (46 %) | ||
| TT | 9 (10 %) | 5 (5 %) | 15 (16 %) | 14 (8 %) |
Associations between CARD8 rs2043211 genotypes and alcohol-related mental disorders
| Mental disorder | CARD8 genotype | Hospitalised alcohol-dependent patients | Abstinent alcohol-dependent subjects | Controls | |||
|---|---|---|---|---|---|---|---|
| Mean score±SD | p-value | Mean score±SD | p-value | Mean score±SD | p-value | ||
| AA | 3.6±4.0 | 0.244 | 1.4±1.9 | 0.203 | 1.5±1.3 | 0.591 | |
| AT | 2.7±5.1 | 2.0±2.0 | 1.8±1.7 | ||||
| TT | 2.2±2.2 | 2.8±4.0 | 1.8±1.3 | ||||
| AA | 2.9±3.5 | 0.481 | 1.3±1.9 | 0.960 | 1.2±0.6 | 0.406 | |
| AT | 3.0±2.9 | 1.5±1.3 | 1.4±1.2 | ||||
| TT | 1.7±1.7 | 1.4±0.9 | 1.3±0.6 | ||||
| AA | 10.2±8.8 | 0.291 | 11.7±8.2 | 0.567 | 10.9±7.7 | 0.695 | |
| AT | 12.7±11.5 | 13.9±12.3 | 10.2±7.0 | ||||
| TT | 16.0±10.3 | 13.2±10.8 | 9.1±4.4 | ||||
| AA | 16.2±11.6 | 0.161 | 3.5±2.7 | 0.401 | 3.5±1.4 | ||
| AT | 18.9±10.9 | 2.9±2.0 | 3.9±2.0 | ||||
| TT | 24.1±10.8 | 2.5±0.9 | 2.6±0.8 | ||||
| AA | 34.1±8.3 | 0.560 | 30.0±6.7 | 0.418 | 23.5±4.3 | 0.201 | |
| AT | 36.6±11.7 | 31.5±8.0 | 22.1±3.3 | ||||
| TT | 37.1±16.3 | 33.6±6.5 | 23.4±3.7 | ||||
| AA | 32.9±6.2 | 0.320 | 29.1±5.6 | 23.0±3.5 | 0.477 | ||
| AT | 35.5±9.1 | 30.8±7.4 | 22.1±2.7 | ||||
| TT | 36.1±10.6 | 36.4±9.5 | 22.5±2.5 | ||||
| AA | 26.0±8.7 | 0.534 | 19.8±8.3 | 0.758 | 15.0±9.0 | 0.970 | |
| AT | 23.3±11.6 | 20.7±11.9 | 14.2±9.3 | ||||
| TT | 23.4±11.6 | 23.0±10.3 | 14.3±6.5 | ||||
| AA | 23.4±6.5 | 0.818 | |||||
| AT | 23.9±7.2 | ||||||
| TT | 22.3±5.4 | ||||||