<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Introduction</h3>
<p>Research on the possibility of increasing the effects of after-injury reconstruction of peripheral nerves conducted in the Department of Physiology at ŚUM resulted in the development of a new method of reconstruction after peripheral nerve injuries. In this new method, we used 7-day predegenerated <italic>in situ</italic> sural nerve grafts. In clinical assessment, we concluded that recovery in motor, sensory and vegetative function after peripheral nerve injury treatment is better with the use of predegenerated grafts. The latent efficacy of reconstruction was measured months or years after reconstruction. In that amount of time, denervated synaptic sites in muscles can be reinnervated by nearby healthy non-injured nerves. It could increase motor, sensory, or vegetative function, irrespective of the effects of chirurgical treatment. We decided to investigate whether the circumstances may influence the latent efficiency of the new method of reconstruction.</p>
</sec>
<sec><h3>Materials and Methods</h3>
<p>Experiments were carried out on 32 patients in The Department of Neurosurgery Medical University of Silesia. Twenty patients were operated on with a predegenerated (P) implant, and 12 patients operated in the traditional method (T). As a result, 25% of patients’ reinnervation from healthy nearby nerves in the area supplied by reconstructed nerves was present. In group P, reinnervation appeared in 7 of 20 patients (35%) and in group T, in 1 from 12 (8.33%) cases.</p>
</sec>
<sec><h3>Results</h3>
<p>Results of the examinations were counted statistically in both groups.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>Reinnervation from nearby healthy non-injured nerves positively influences the results of human peripheral nerve reconstruction.</p>
</sec>
</abstract>

Introduction
Research on the possibility of increasing the effects of after-injury reconstruction of peripheral nerves conducted in the Department of Physiology at ŚUM resulted in the development of a new method of reconstruction after peripheral nerve injuries. In this new method, we used 7-day predegenerated in situ sural nerve grafts. In clinical assessment, we concluded that recovery in motor, sensory and vegetative function after peripheral nerve injury treatment is better with the use of predegenerated grafts. The latent efficacy of reconstruction was measured months or years after reconstruction. In that amount of time, denervated synaptic sites in muscles can be reinnervated by nearby healthy non-injured nerves. It could increase motor, sensory, or vegetative function, irrespective of the effects of chirurgical treatment. We decided to investigate whether the circumstances may influence the latent efficiency of the new method of reconstruction.

Materials and Methods
Experiments were carried out on 32 patients in The Department of Neurosurgery Medical University of Silesia. Twenty patients were operated on with a predegenerated (P) implant, and 12 patients operated in the traditional method (T). As a result, 25% of patients’ reinnervation from healthy nearby nerves in the area supplied by reconstructed nerves was present. In group P, reinnervation appeared in 7 of 20 patients (35%) and in group T, in 1 from 12 (8.33%) cases.

Results
Results of the examinations were counted statistically in both groups.

Conclusion
Reinnervation from nearby healthy non-injured nerves positively influences the results of human peripheral nerve reconstruction.

The influence of reinnervation on the results of peripheral nerve repair after injuries

Department of Sports Medicine and Physiology of Physical Exercise, Faculty of Health Sciences in Katowice

Medical University of Silesia in Katowice

Chair and Department of Physiology, Faculty of Medical Sciences in Katowice

Center of Experimental Medicine of the Medical University of Silesia in Katowice

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Introduction
Research on the possibility of increasing the effects of after-injury reconstruction of peripheral nerves conducted in the Department of...

The influence of reinnervation on the results of peripheral nerve repair after injuries

Article Category: Original Study

Published Online: Oct 20, 2023

Page range: 118 - 124

Received: Oct 14, 2022

Accepted: Mar 21, 2023

DOI: https://doi.org/10.2478/ahem-2023-0012

Keywords
reinnervation, predegeneration, peripheral nerve, nerve reconstruction

© 2023 Krzysztof Suszyński et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The influence of reinnervation on the results of peripheral nerve repair after injuries

Article Category: Original Study

Published Online: Oct 20, 2023

Page range: 118 - 124

Received: Oct 14, 2022

Accepted: Mar 21, 2023

DOI: https://doi.org/10.2478/ahem-2023-0012

Keywordsreinnervation, predegeneration, peripheral nerve, nerve reconstruction

© 2023 Krzysztof Suszyński et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
reinnervation, predegeneration, peripheral nerve, nerve reconstruction