Ketamine used in the therapy of depressive disorders impacts protein profile, proliferation rate, and phagocytosis resistance of enterococci

Fig. 1

Fig. 2

Source of strains

Source	Number of strains
Upper respiratory tract	6
Cervical canal	4
Vagina	4
Wound	5
Urine (> 106 cfu/mL)	4
Bedsore	3
Sperm	1

Changes of relative values of protein peak after incubation of the enterococcal strains with ketamine_ Group A+: strains increasing proliferation when cultured with ketamine; group B+ strains inhibited by ketamine; group A and B – strains cultured without ketamine_ Grey bars: peaks typical for Enterococcus faecalis according to Stępień-Pyśniak D et al_ [24]_ Dark grey bars: the highest protein peak for all the measurements, considered as baseline for observed levels in other protein peaks (group A and B) and after the exposure to ketamine (group A+ and B+)_ Green color underlines the increase of peak value; the red color indicates decreased or missing peak when compared to strains not exposed to ketamine

Reference	m/z	Group A	Group A +	Group B	Group B +
Stępień-Pyśniak D	2211	67	88	0	25
	2663	29	0	0	17
	3421	29	29	33	20
	3669	26	35	24	0
	4439	100	100	100	100
	4778	28	37	22	17
	5361	53	40	38	62
	6084	14	16	15	10
	6231	14	15	18	0
	6403	25	24	31	26
	6839	31	32	40	38
	7326	42	59	42	13
	7572	23	0	23	19
	8911	12	15	21	12
	9544	27	35	23	26