<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>During the development of medicinal forms (eye drops), it is necessary to consider several parameters, so that the medicine is nonirritating to the eye and, at the same time, has the desired effect. We prepared eye drops containing dexamethasone or its water-soluble salt in a 0.1% concentration. We compared suspension eye drops (with dexamethasone) and solution eye drops (with dexamethasone sodium phosphate) without viscosity adjustment as well as with viscosity adjustment by adding chitosan low molecular weight (LMW) with the mass-produced product Unidexa 1%. Acidity (pH), surface tension, density, viscosity, and irritability were evaluated. An <italic>in vitro</italic> or <italic>ex vivo</italic> test on human erythrocytes (red blood cells [RBCs]) was used to test irritability. Hemolysis of RBC was monitored by determining hemoglobin spectrophotometrically at a wavelength of 550 nm. The addition of chitosan 0.1% as a viscosity-increasing agent reduced the irritation potential of the experimental eye drops.</p>
</abstract>

During the development of medicinal forms (eye drops), it is necessary to consider several parameters, so that the medicine is nonirritating to the eye and, at the same time, has the desired effect. We prepared eye drops containing dexamethasone or its water-soluble salt in a 0.1% concentration. We compared suspension eye drops (with dexamethasone) and solution eye drops (with dexamethasone sodium phosphate) without viscosity adjustment as well as with viscosity adjustment by adding chitosan low molecular weight (LMW) with the mass-produced product Unidexa 1%. Acidity (pH), surface tension, density, viscosity, and irritability were evaluated. An in vitro or ex vivo test on human erythrocytes (red blood cells [RBCs]) was used to test irritability. Hemolysis of RBC was monitored by determining hemoglobin spectrophotometrically at a wavelength of 550 nm. The addition of chitosan 0.1% as a viscosity-increasing agent reduced the irritation potential of the experimental eye drops.

Evaluation of Properties of Dexamethasone Eye Drops

Faculty of Pharmacy, Department of Galenic Pharmacy

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Evaluation of Properties of Dexamethasone Eye Drops"}

During the development of medicinal forms (eye drops), it is necessary to consider several parameters, so that the medicine is nonirritating to the eye and, at...

Evaluation of Properties of Dexamethasone Eye Drops

Article Category: Special Issue Article

Published Online: Aug 24, 2023

Page range: 52 - 57

Received: Jun 21, 2023

Accepted: Jun 22, 2023

DOI: https://doi.org/10.2478/afpuc-2023-0009

Keywords
dexamethasone, chitosan, irritation, erythrocytes

© 2023 D. Matušová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Evaluation of Properties of Dexamethasone Eye Drops

Article Category: Special Issue Article

Published Online: Aug 24, 2023

Page range: 52 - 57

Received: Jun 21, 2023

Accepted: Jun 22, 2023

DOI: https://doi.org/10.2478/afpuc-2023-0009

Keywordsdexamethasone, chitosan, irritation, erythrocytes

© 2023 D. Matušová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
dexamethasone, chitosan, irritation, erythrocytes