<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The goal of the present study is to prepare a stable, multiple-unit, extended-release dosage form containing oxycodone pellets coated with aqueous ethylcellulose (EC) dispersion, Surelease E-7-19050. The application of 18% w/w of EC leads to the similar drug release with the hydrophobic, non-swelling, matrix reference product containing 20 mg of oxycodone. Increasing the compression force to 9 kN and including more than 50% w/w of oxycodone pellets into the formulation resulted in faster drug release, indicating the damaging to the EC film coating. The physical appearance of the final formulation, assay of oxycodone, moisture content, and dissolution data over the stability period showed that the multiple-unit pellet system (MUPS) is efficient for the production of highly stable product.</p>
</abstract>

The goal of the present study is to prepare a stable, multiple-unit, extended-release dosage form containing oxycodone pellets coated with aqueous ethylcellulose (EC) dispersion, Surelease E-7-19050. The application of 18% w/w of EC leads to the similar drug release with the hydrophobic, non-swelling, matrix reference product containing 20 mg of oxycodone. Increasing the compression force to 9 kN and including more than 50% w/w of oxycodone pellets into the formulation resulted in faster drug release, indicating the damaging to the EC film coating. The physical appearance of the final formulation, assay of oxycodone, moisture content, and dissolution data over the stability period showed that the multiple-unit pellet system (MUPS) is efficient for the production of highly stable product.

Formulation and evaluation of new oxycodone extended release multiple unit pellet system

Faculty of Pharmacy, Department of Pharmaceutical chemistry

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The goal of the present study is to prepare a stable, multiple-unit, extended-release dosage form containing oxycodone pellets coated with aqueous...

Formulation and evaluation of new oxycodone extended release multiple unit pellet system

Published Online: Jan 28, 2020

Page range: 4 - 10

Received: Mar 06, 2019

Accepted: Aug 16, 2019

DOI: https://doi.org/10.2478/afpuc-2019-0019

Keywords
Opioids, Oxycodone, Dissolution, Extended release, Pellets

© 2019 Š. Husár et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Formulation and evaluation of new oxycodone extended release multiple unit pellet system

Published Online: Jan 28, 2020

Page range: 4 - 10

Received: Mar 06, 2019

Accepted: Aug 16, 2019

DOI: https://doi.org/10.2478/afpuc-2019-0019

KeywordsOpioids, Oxycodone, Dissolution, Extended release, Pellets

© 2019 Š. Husár et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Opioids, Oxycodone, Dissolution, Extended release, Pellets