<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Valproic acid, beside its anticonvulsant action, is widely used as a mood stabilizer in the therapy of bipolar disorder. The potential antidepressant action of valproic acid has not been sufficiently characterized so far. The aim of the present study was to evaluate the antidepressant effect of valproic acid in an aldosterone model of depression. Subchronic treatment with valproic acid resulted in a reduction of the time spent in immobility in the forced swim test. In conclusion, the present study provides evidence on antidepressant effects of valproic acid using a classical behavioral approach for testing the efficacy of antidepressant drug in animal models.</p>
</abstract>

Valproic acid, beside its anticonvulsant action, is widely used as a mood stabilizer in the therapy of bipolar disorder. The potential antidepressant action of valproic acid has not been sufficiently characterized so far. The aim of the present study was to evaluate the antidepressant effect of valproic acid in an aldosterone model of depression. Subchronic treatment with valproic acid resulted in a reduction of the time spent in immobility in the forced swim test. In conclusion, the present study provides evidence on antidepressant effects of valproic acid using a classical behavioral approach for testing the efficacy of antidepressant drug in animal models.

Antidepressant effects of valproic acid in an animal model of depression

Faculty of Pharmacy, Department of Pharmacology and Toxicology

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Antidepressant effects of valproic acid in an animal model of depression"}

Valproic acid, beside its anticonvulsant action, is widely used as a mood stabilizer in the therapy of bipolar disorder. The potential antidepressant action of...

Antidepressant effects of valproic acid in an animal model of depression

Published Online: Jan 28, 2020

Page range: 1 - 3

Received: May 18, 2019

Accepted: May 22, 2019

DOI: https://doi.org/10.2478/afpuc-2019-0006

Keywords
sodium valproate, forced swimming test, antidepressant effect

© 2019 K. Buzgoova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antidepressant effects of valproic acid in an animal model of depression

Published Online: Jan 28, 2020

Page range: 1 - 3

Received: May 18, 2019

Accepted: May 22, 2019

DOI: https://doi.org/10.2478/afpuc-2019-0006

Keywordssodium valproate, forced swimming test, antidepressant effect

© 2019 K. Buzgoova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
sodium valproate, forced swimming test, antidepressant effect