1. bookVolume 66 (2019): Issue 1 (June 2019)
Journal Details
License
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Journal
First Published
25 Nov 2011
Publication timeframe
2 times per year
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English
access type Open Access

Total DNA methylation in the brain in response to decitabine treatment in female rats

Published Online: 26 Dec 2019
Page range: 1 - 3
Received: 18 Mar 2019
Accepted: 30 May 2019
Journal Details
License
Format
Journal
First Published
25 Nov 2011
Publication timeframe
2 times per year
Languages
English

Hypomethylating agent decitabine is being used in the treatment of certain types of leukaemia in combination with other anticancer drugs. Aberrant DNA methylation has been suggested to occur in pathological states including depression. Scarce data in male rats suggest antidepressant effects of decitabine. The main aim of our studies is to test the hypothesis that the inhibition of DNA methylation results in antidepressant effects in female rats. Before doing so, we decided to verify the effects of decitabine on DNA methylation in females. The findings demonstrate that the treatment with decitabine at the dose shown previously to inhibit DNA methylation in males, had no effect on total DNA methylation in two brain regions, namely the hippocampus and frontal cortex of female rats. In conclusion, the present study allows us to suggest that the effect of decitabine on DNA methylation in the brain is sex dependent.

Keywords

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