<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In our paper, we demonstrate several possibilities of using neutrons in pharmaceutical research with the help of examples of scientific results achieved at our University. In this first part, basic properties of neutrons and elementary principles of elastic scattering of thermal neutrons are described. Results of contrast variation neutron diffraction on oriented phospholipid bilayers with intercalated local anaesthetic or cholesterol demonstrate the potential of this method at determination of their position in bilayers. Diffraction experiments with alkan-1-ols located in the bilayers revealed their influence on bilayer thickness as a function of their alkyl chain length.</p></abstract>

In our paper, we demonstrate several possibilities of using neutrons in pharmaceutical research with the help of examples of scientific results achieved at our University. In this first part, basic properties of neutrons and elementary principles of elastic scattering of thermal neutrons are described. Results of contrast variation neutron diffraction on oriented phospholipid bilayers with intercalated local anaesthetic or cholesterol demonstrate the potential of this method at determination of their position in bilayers. Diffraction experiments with alkan-1-ols located in the bilayers revealed their influence on bilayer thickness as a function of their alkyl chain length.

Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction

Comenius University in Bratislava, Faculty of Mathematics, Physics and Informatics, Department of Nuclear Physics and Biophysics, Slovak republic

Comenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs, Slovak republic

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In our paper, we demonstrate several possibilities of using neutrons in pharmaceutical research with the help of examples of scientific results achieved at our...

Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction

Published Online: Dec 30, 2014

Page range: 1 - 11

DOI: https://doi.org/10.2478/afpuc-2014-0010

Keywords
neutron diffraction, phospholipid bilayer, local anaesthetic, alkan-1-ols, cholesterol

© Acta Facultatis Pharmaceuticae Universitatis Comenianae

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction

Published Online: Dec 30, 2014

Page range: 1 - 11

DOI: https://doi.org/10.2478/afpuc-2014-0010

Keywordsneutron diffraction, phospholipid bilayer, local anaesthetic, alkan-1-ols, cholesterol

© Acta Facultatis Pharmaceuticae Universitatis Comenianae

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
neutron diffraction, phospholipid bilayer, local anaesthetic, alkan-1-ols, cholesterol