<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Congenital hepatic fibrosis (CHF) is a rare condition characterized by abnormal accumulation of fibrous tissue in the liver, leading to liver dysfunction. While CHF has been documented in various animal species, it has rarely been reported in cattle. This report presents a case of CHF in an aborted Holstein-Friesian fetus. During the necropsy, the most notable macroscopic findings included an enlarged liver with an irregular “cobblestone appearance” on the surface and firm parenchyma, as well as moderate ascites. Histopathological examination revealed extensive hepatic fibrosis in the portal areas, accompanied by bridging fibrosis extending between portal tracts and bile duct proliferation within the fibrous tissue. Screening for infectious agents as the cause of abortion or liver lesions was unremarkable. The necropsy and histopathological findings confirmed CHF, constituting the first case described in Holstein-Friesian calves in Serbia. Further research is required to determine whether this condition has a genetic basis or is influenced by yet to be identified factors in Holstein-Friesian cattle.</p>
</abstract>

Congenital hepatic fibrosis (CHF) is a rare condition characterized by abnormal accumulation of fibrous tissue in the liver, leading to liver dysfunction. While CHF has been documented in various animal species, it has rarely been reported in cattle. This report presents a case of CHF in an aborted Holstein-Friesian fetus. During the necropsy, the most notable macroscopic findings included an enlarged liver with an irregular “cobblestone appearance” on the surface and firm parenchyma, as well as moderate ascites. Histopathological examination revealed extensive hepatic fibrosis in the portal areas, accompanied by bridging fibrosis extending between portal tracts and bile duct proliferation within the fibrous tissue. Screening for infectious agents as the cause of abortion or liver lesions was unremarkable. The necropsy and histopathological findings confirmed CHF, constituting the first case described in Holstein-Friesian calves in Serbia. Further research is required to determine whether this condition has a genetic basis or is influenced by yet to be identified factors in Holstein-Friesian cattle.

Congenital Hepatic Fibrosis in an Aborted Holstein-Friesian Fetus

Agriculture Faculty, Department of Veterinary Medicine

Acta Veterinaria

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Congenital Hepatic Fibrosis in an Aborted Holstein-Friesian Fetus"}

Congenital hepatic fibrosis (CHF) is a rare condition characterized by abnormal accumulation of fibrous tissue in the liver, leading to liver dysfunction....

Congenital Hepatic Fibrosis in an Aborted Holstein-Friesian Fetus

Article Category: Case report

Published Online: Jun 24, 2024

Page range: 313 - 321

Received: Oct 24, 2023

Accepted: Apr 05, 2024

DOI: https://doi.org/10.2478/acve-2024-0022

Keywords
congenital hepatic fibrosis, Holstein-Friesian calf

© 2024 Božidar Savić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Congenital Hepatic Fibrosis in an Aborted Holstein-Friesian Fetus

Article Category: Case report

Published Online: Jun 24, 2024

Page range: 313 - 321

Received: Oct 24, 2023

Accepted: Apr 05, 2024

DOI: https://doi.org/10.2478/acve-2024-0022

Keywordscongenital hepatic fibrosis, Holstein-Friesian calf

© 2024 Božidar Savić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
congenital hepatic fibrosis, Holstein-Friesian calf