<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>An 11-year-old male Cocker Spaniel was presented with acute onset of apathy, polyuria and polydipsia. Blood examination showed hypoalbuminemia and hyperglobulinemia, while electrophoresis revealed monoclonal gammopathy. Subsequent tests showed glycosuria, proteinuria, a positive serology test for <italic>Anaplasma spp</italic>. and ultrasonographical changes of the liver and spleen. Urine electrophoresis confirmed the presence of Bence-Jones protein. The dog’s condition deteriorated, and the dog had developed skin lesions on the neck and body. The owner decided to euthanize the dog and agreed to bone marrow and skin biopsy. Bone marrow cytology revealed an increased number of plasma cells and several cellular atypia. Histopathology of the skin lesions showed a round cell tumor of lymphoid or plasmacytoid origin. Subsequent immunohistology supported the diagnosis of multiple myeloma cutaneous involvement.</p>
<p>This case report describes unusual features observed in a dog with multiple myeloma.</p>
</abstract>

An 11-year-old male Cocker Spaniel was presented with acute onset of apathy, polyuria and polydipsia. Blood examination showed hypoalbuminemia and hyperglobulinemia, while electrophoresis revealed monoclonal gammopathy. Subsequent tests showed glycosuria, proteinuria, a positive serology test for Anaplasma spp. and ultrasonographical changes of the liver and spleen. Urine electrophoresis confirmed the presence of Bence-Jones protein. The dog’s condition deteriorated, and the dog had developed skin lesions on the neck and body. The owner decided to euthanize the dog and agreed to bone marrow and skin biopsy. Bone marrow cytology revealed an increased number of plasma cells and several cellular atypia. Histopathology of the skin lesions showed a round cell tumor of lymphoid or plasmacytoid origin. Subsequent immunohistology supported the diagnosis of multiple myeloma cutaneous involvement.
This case report describes unusual features observed in a dog with multiple myeloma.

Multiple Myeloma with Skin and Renal Involvement and <italic>Anaplasma Phagocytophilum</italic> Co-Infection in a Dog

University of Veterinary Medicine and Pharmacy

Acta Veterinaria

This work is licensed under the Creative Commons Attribution 4.0 International License.

Multiple Myeloma with Skin and Renal Involvement and  Co-Infection in a Dog

An 11-year-old male Cocker Spaniel was presented with acute onset of apathy, polyuria and polydipsia. Blood examination showed hypoalbuminemia and...

Multiple Myeloma with Skin and Renal Involvement and Anaplasma Phagocytophilum Co-Infection in a Dog

Published Online: Jul 04, 2022

Page range: 276 - 286

Received: Nov 04, 2021

Accepted: May 06, 2022

DOI: https://doi.org/10.2478/acve-2022-0022

Keywords
anaplasmosis, glycosuria, monoclonal gammopathy, plasma cell, skin metastasis

© 2022 Hana Turna et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Multiple Myeloma with Skin and Renal Involvement and Anaplasma Phagocytophilum Co-Infection in a Dog

Published Online: Jul 04, 2022

Page range: 276 - 286

Received: Nov 04, 2021

Accepted: May 06, 2022

DOI: https://doi.org/10.2478/acve-2022-0022

Keywordsanaplasmosis, glycosuria, monoclonal gammopathy, plasma cell, skin metastasis

© 2022 Hana Turna et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
anaplasmosis, glycosuria, monoclonal gammopathy, plasma cell, skin metastasis