<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Metaplasia is a transformation of one mature cell type to other kinds of mature cells. Metaplasia is hardly detected in benign tumors, whereas it is frequently observed in malignant tumors. In this study, we report the first case of osseous metaplasia in canine leiomyoma. The region of osseous metaplasia was highly eosinophilic and had various sizes of distinct lacunae. The osseoid material was confirmed by Von Kossa staining. Except for the osseous metaplasia, the mass presented typical features of leiomyoma without any histopathological features of malignancy. The characteristics of malignant tumors, including pleomorphism, mitotic figures, and lymphatic metastasis were not identified and the mass was proven to be a benign tumor. The osseous metaplasia in leiomyoma without dysplastic changes might be due to plasticity which is a unique feature of smooth muscle cells, whether the tumor is malignant or not. This case suggests the possible occurrence of osseous metaplasia in leiomyoma, which has been overlooked due to the lack of reports. Also, it is recommended to pay attention to making a diagnosis of smooth muscle tumor with metaplasia so as not to be confused with leiomyosarcoma and leiomyoma variants.</p>
</abstract>

Metaplasia is a transformation of one mature cell type to other kinds of mature cells. Metaplasia is hardly detected in benign tumors, whereas it is frequently observed in malignant tumors. In this study, we report the first case of osseous metaplasia in canine leiomyoma. The region of osseous metaplasia was highly eosinophilic and had various sizes of distinct lacunae. The osseoid material was confirmed by Von Kossa staining. Except for the osseous metaplasia, the mass presented typical features of leiomyoma without any histopathological features of malignancy. The characteristics of malignant tumors, including pleomorphism, mitotic figures, and lymphatic metastasis were not identified and the mass was proven to be a benign tumor. The osseous metaplasia in leiomyoma without dysplastic changes might be due to plasticity which is a unique feature of smooth muscle cells, whether the tumor is malignant or not. This case suggests the possible occurrence of osseous metaplasia in leiomyoma, which has been overlooked due to the lack of reports. Also, it is recommended to pay attention to making a diagnosis of smooth muscle tumor with metaplasia so as not to be confused with leiomyosarcoma and leiomyoma variants.

A Rare Case of Osseous Metaplasia in Canine Leiomyoma and Plasticity of Smooth Muscle Cell

Acta Veterinaria

This work is licensed under the Creative Commons Attribution 4.0 International License.

Metaplasia is a transformation of one mature cell type to other kinds of mature cells. Metaplasia is hardly detected in benign tumors, whereas it is frequently...

A Rare Case of Osseous Metaplasia in Canine Leiomyoma and Plasticity of Smooth Muscle Cell

Published Online: Jul 04, 2022

Page range: 268 - 275

Accepted: Mar 30, 2022

DOI: https://doi.org/10.2478/acve-2022-0021

Keywords
Osseous metaplasia, smooth muscle, benign, leiomyoma, dog

© 2022 Eun-Joo Lee et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

A Rare Case of Osseous Metaplasia in Canine Leiomyoma and Plasticity of Smooth Muscle Cell

Published Online: Jul 04, 2022

Page range: 268 - 275

Accepted: Mar 30, 2022

DOI: https://doi.org/10.2478/acve-2022-0021

KeywordsOsseous metaplasia, smooth muscle, benign, leiomyoma, dog

© 2022 Eun-Joo Lee et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
Osseous metaplasia, smooth muscle, benign, leiomyoma, dog