1. bookVolume 70 (2020): Issue 1 (March 2020)
Journal Details
First Published
25 Mar 2014
Publication timeframe
4 times per year
access type Open Access

Current Swine Respiratory Diseases Morphology in Intensive Swine Production in Serbia

Published Online: 03 Apr 2020
Volume & Issue: Volume 70 (2020) - Issue 1 (March 2020)
Page range: 1 - 36
Accepted: 11 Mar 2020
Journal Details
First Published
25 Mar 2014
Publication timeframe
4 times per year

Swine respiratory diseases represent one of the most frequent health issues in pig production worldwide. Despite the great progress that has been made in the field of diagnostics, control and prophylaxis, respiratory diseases still remain the most challenging health problem in modern commercial pig production. The list of infectious agents that cause respiratory diseases in swine is extensive and includes both, bacterial and viral pathogens. In Serbia, more than fifteen years after the introduction of modern vaccines, the list of bacterial pathogens related to swine respiratory infections still include Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Haemophilus parasuis and Pasteurella multocida. On the other hand, most commonly involved viral pathogens are Porcine Reproductive and Respiratory Syndrome Virus, Swine influenza virus, Porcine circovirus type 2 and Pseudorabies virus. The morphological features of pneumonia where several agents are involved, depend on the predominant etiological agent. Expanding knowledge of the main pathogens associated with swine respiratory diseases and the effects of their interactions on the disease outcome is important for further investigations of lung diseases and implementation of control strategies in commercial pig populations in Serbia. This review discusses the latest findings on swine respiratory disease and current trends in Serbian pig production.


1. Christensen VS, Sorensen V, Mousing J: Diseases of the Respiratory System. In: Straw BE, D’Allaire S, Mengeling WL, Taylor DJ (Eds.), Diseases of Swine, 8th ed. Ames, Iowa: Iowa State University Press. 1999, 913-941.Search in Google Scholar

2. Sorensen V, Jorsal SE, Mousing J: Diseases of the respiratory system. In: Straw B, Zimmermann W, D’Allaire S, Taylor DJ (Eds.). Diseases of Swine, 9th ed. Ames, Iowa: Iowa State University Press. 2006, 149–177.Search in Google Scholar

3. Carr J, Chen S-P, Connor JF, Kirkwood R, Segales J: Respiratory Disorders. In: Pig Health. New York, USA: CRC Press Taylor & Francis Group. 2018, 103-111.10.1201/9781315157061-3Search in Google Scholar

4. Fablet C, Marois-Crehan C, Simon G, Grasland B, Jestin A, Kobisch M, Madec F, Rose N: Infectious agents associated with respiratory diseases in 125 farrow-to-finish pig herds: A cross-sectional study. Vet Microbiol. 2012, 157:152–163.10.1016/j.vetmic.2011.12.01522226820Search in Google Scholar

5. Laanen M, Persoons D, Ribbens S, de Jong E, Callens B, Strubbe M, Maes D, Dewulf J: Relationship between biosecurity and production/antimicrobial treatment characteristics in pig herds. Vet. J. 2013, 198(2):508-12.Search in Google Scholar

6. Karabasil N, Čobanović N, Vučićević I, Stajković S, Becskei Z, Forgach P, Aleksic – Kovačević S: Association of the severity of lung lesions with carcass and meat quality in slaughter pigs. Acta Hungarica. 2017, 65(3): 354-365.Search in Google Scholar

7. Merialdi G, Dottori M, Bonilauri P, Luppi A, Gozio S, Pozzi P, Spaggiari B, Martelli P: Survey of pleuritis and pulmonary lesions in pigs at abattoir with a focus on the extent of the condition and herd risk factors. Vet. J. 2012, 193:234-239.10.1016/j.tvjl.2011.11.00922182431Search in Google Scholar

8. Baraldi TG, Cruz NRN, Pereira DA, Galdeano JVB, Gatto IRH, Silva AFD, Panzardi A, Linhares DCL, Mathias LA, de Oliveira LG: Antibodies against Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae and influenza virus and their relationships with risk factors, clinical signs and lung lesions in pig farms with one-site production systems in Brazil. Prev. Vet. Med. 2019, 171: 104748.10.1016/j.prevetmed.2019.10474831470290Search in Google Scholar

9. Prodanov-Radulović J, Došen R, Stojanov I, Petrović T, Polaček V, Grgić Ž, Marčić D: Etiology and diagnostics of porcine respiratory syndrome on a pig farm in the Republic of Serbia. Proceedings 7th ESPHM, Nantes, France. 2015, 147.Search in Google Scholar

10. Meyns T, Van Steelant J, Rolly E, Dewulf J, Haesebrouk F, Maes D: A cross-sectional study of risk factors associated with pulmonary lesions in pigs at slaughter. Vet. J. 2011, 187: 388-392.10.1016/j.tvjl.2009.12.02720122861Search in Google Scholar

11. Zhao Z, Wang C, Xue y, Tang X, Wu B, Cheng X, He Q,, Chen H: The occurrence of Bordetella bronchiseptica in pigs with clinical respiratory disease. Vet. J. 2011, 188:337-340.10.1016/j.tvjl.2010.05.02220598597Search in Google Scholar

12. Maes D, Segales J, Meyns T, Sibila M, Pieters M, Haesebrouck F: Control of Mycoplasma hyopneumoniae infections in pigs. Vet Microbiol. 2008, 126:297–309.10.1016/j.vetmic.2007.09.008713072517964089Search in Google Scholar

13. Maes D, Sibila M, Kuhnert P, Segales J, Haesebrouck F, Pieters M: Update on Mycoplasma hyopneumoniae infections in pigs: knowledge gaps for improved disease control. Transbound. Emerg. Dis. 2018, 65:110-124.10.1111/tbed.1267728834294Search in Google Scholar

14. Garza-Moreno L, Segales J, Aragon V, Correa-Fiz F, Pieters M, Carmona M, Krejci R, Sibila M: Characterization of Mycoplasma hyopneumoniae strains in vaccinated and nonvaccinated pigs from Spanish slaughterhouses. Vet Microbiol. 2019, 231:18-23.10.1016/j.vetmic.2019.02.02330955807Search in Google Scholar

15. Opriessnig T, Giménez-Lirola L, & Halbur P: Polymicrobial respiratory disease in pigs. Animal Health Research Reviews. 2011, 12(2):133-148.10.1017/S146625231100012022152290Search in Google Scholar

16. Sibila M, Pieters M, Molitor T, Maes D, Haesebrouck F, Segales J: Current perspectives on the diagnosis and epidemiology of Mycoplasma hyopneumoniae infection. Vet. J. 2009,181:221–231.10.1016/j.tvjl.2008.02.020711080518396428Search in Google Scholar

17. Tobias TJ, Raymakers RJ, van Nes A, van Leengoed LA: Outbreak of respiratory distress resembling influenza caused by Actinobacillus pleuropneumoniae in pigs. Vet. Rec. 2009, 164:402-403.10.1136/vr.164.13.40219329810Search in Google Scholar

18. Fablet C, Marois-Crehan C, Grasland B, Simon G, Rose N: Factors associated with herd-level PRRSV infection and age-time to seroconversion in farrow-to-finish herds. Vet Microbiol. 2016, 10-20.10.1016/j.vetmic.2016.06.00627527759Search in Google Scholar

19. Opriessnig T, Langohr I: Current state of knowledge on porcine circovirus type 2– associated lesions. Vet Pathol. 2012, 50(1):23-38.Search in Google Scholar

20. Toplak I, Lazić S, Lupulović D, Prodanov-Radulović J, Becskei Z, Došen R, Petrović T: Study of the genetic variability of porcine Circovirus type 2 detected in Serbia and Slovenia. Acta Veterinaria Hungarica, 2012, 60 (3):409-420.10.1556/avet.2012.03522903085Search in Google Scholar

21. Stadejek T, Oleksiewicz MB, Scherbakov AV, Timina AM, Krabbe JS, Chabros K, Potapchuk D: Definition of subtypes in the European genotype of porcine reproductive and respiratory syndrome virus: nucleocapsin characteristics and geographical distribution in Europe. Arch Virol 2008, 153:1479-88.10.1007/s00705-008-0146-218592131Search in Google Scholar

22. Pomorska-Mol D, Dors A, Kwit K, Kowalczyk A, Stasiak E, Pejsak Z: Kinetics of single and dual infection of pigs with swine influenza virus and Actinobacillus pleuropneumoniae. Vet Microbiol. 2017, 201:113-120.10.1016/j.vetmic.2017.01.01128284596Search in Google Scholar

23. Prodanov-Radulović J, Došen R, Pušić I, Stojanov I, Lupulović D, Ratajac R: The transmission and spreading routes of Aujeszky’s disease in swine population. Biotechnol. Anim. Husb. 2011, 867-874.10.2298/BAH1103867PSearch in Google Scholar

24. Prodanov-Radulović J, Došen R, Pušić I, Petrović T, Apić J, Stojanov I, Polaček V: Emergence of pseudorabies virus (Morbus aujeszky) infection at large swine farms in AP Vojvodina (Serbia). Contemporary agriculture. 2015, 105-111.Search in Google Scholar

25. Prodanov-Radulović J, Došen R, Polaček V, Petrović T, Stojanov I, Ratajac R, Valčić M: Classical swine fever: active immunization of piglets with subunit (E2) vaccine in the presence of different levels of colostral immunity (China strain). Acta Veterinaria-Beograd 2014, 64(4): 493-509.10.2478/acve-2014-0046Search in Google Scholar

26. Polaček V, Prodanov-Radulović J, Došen R, Petrović T, Becskei Z, Aleksić-Kovačević S: Expression of E2 (gp 55) glycoprotein of classical swine fever virus in lymphoid tissue and brain of experimentally infected piglets with different immunological status. Acta veterinaria-Beograd 2014, 64 (2):213-225.10.2478/acve-2014-0020Search in Google Scholar

27. Prodanov J, Došen R, Pušić I, Bugarski D, Valčić M: Passive immunity evaluation in piglets originating from sows vaccinated with China strain of classical swine fever virus. Acta Veterinaria 2007, 57 (5-6):413-427.10.2298/AVB0706413PSearch in Google Scholar

28. Prodanov-Radulović J, Došen R, Stojanov I, Polaček V, Živkov-Baloš M, Marčić D, Pušić I: The interaction between the swine infectious diseases agents and low levels of mycotoxins in swine feed. Biotechnol. Anim. Husb. 2014,30(3):433-444.Search in Google Scholar

29. Prodanov-Radulović J, Petrović T, Lupulović D, Marčić D, Petrović J, Grgić Ž, Lazić S: First detection and clinical presentation of Porcine epidemic diarrhea virus (PEDV) in Serbia. Acta Veterinaria-Beograd 2017, 67(3):383-396.10.1515/acve-2017-0031Search in Google Scholar

30. Savic B, Radanovic O, Jovicic D, Nesic K, Ivanovic S, Stevancevic O, Cvetojevic Đ, Kasagic D: Survey of infectious agents associated with porcine respiratory disease complex (PRDC) in Serbian swine herds using polymerase chain reaction (PCR) detection. Acta Veterinaria-Beograd 2015, 65(1):79-88.10.1515/acve-2015-0006Search in Google Scholar

31. Prodanov-Radulović J, Živkov-Baloš M, Jakšić S, Grgić Ž, Stojanov I, Bojkovski J, Tassis PD: Aflatoxin M1 levels in sow milk. J HELLENIC VET MED SOC 2017, 68(3): 341-346.10.12681/jhvms.15487Search in Google Scholar

32. Novosel D, Petrović T, Acinger-Rogić Ž, Štukelj M: Epidemiology and status of porcine reproductive and respiratory syndrome in the Western Balkan region: challenges and prospects. Slov Vet Res 2016, 53 (4): 185-93.Search in Google Scholar

33. Petrović T, Milićević V, Prodanov-Radulović J, Maksimović-Zorić J, Lupulović D, Došen R, Lazić S: Molecular detection and genetic analysis of Serbian PRRSV isolates. Proceedings EuroPRRS2011 ‘Understanding and combating PRRS in Europe’ COST Action FA902, 2011, 50-56.Search in Google Scholar

34. Postma M, Backhans A, Collineau L, Loesken S, Sjolund M, Belloc C, Emanuelson U, Grosse Beilage E, Stark KDC, Dewulf J: The biosecurity status and its associations with production and management characteristics in farrow-to-finish pig herds. Animal 2016, 10(3): 478-489.10.1017/S175173111500248726567800Search in Google Scholar

35. Dewulf J. and van Immerseel F. Biosecurity in animal production and veterinary medicine From principles to practice. Acco Leuven, 2018, 12:295-319.10.1079/9781789245684.0295Search in Google Scholar

36. Gottschalk M: The challenge of detecting herds sub-clinically infected with Actinobacillus pleuropneumoniae. Vet. J. 2016, 206:30-38.10.1016/j.tvjl.2015.06.01626206322Search in Google Scholar

37. Hansen MS, Pors SE, Jensen HE, Bille-Hansen V, Bisgaard M, Flachs EM, Nielsen OL: An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark. Journal of Comparative Pathology 2010, 143: 120–131.10.1016/j.jcpa.2010.01.012709441520181357Search in Google Scholar

38. Quinn JP, Markey KB, Leonard CF, Fitz SE, Fanning S, Hartigan JP: Section III Pathogenic Bacteria. In Veterinary microbiology and Microbial disease, UK:Wiley Blackwell, 2011, 179-405.Search in Google Scholar

39. Ma W, Lager KM, Richt JA, Stoffregen WC, Zhou F, Yoon KJ: Development of real-time polymerase chain reaction assays for rapid detection and differentiation of wild-type pseudorabies and gene-deleted vaccine viruses. J. Vet. Diagn. Invest., 2008, 20:440–447.10.1177/10406387080200040518599848Search in Google Scholar

40. Strait EL, Madsen ML, Minion FC, Christopher-Hennings J, Dammen M, Jones KR, Thacker EL: Real-Time PCR Assays To Address Genetic Diversity among Strains of Mycoplasma hyopneumoniae. J Clin Microbiol. 2008, 46 (8):2491–2498.10.1128/JCM.02366-07251950918524960Search in Google Scholar

41. Brauer C, Hennig-Pauka I, Hoeltig D, Buettner FF, Beyerbach M, Gasse H, Gerlach GF, Waldmann KH: Experimental Actinobacillus pleuropneumoniae challenge in swine: comparison of computed tomographic and radiographic findings during disease. BMC Vet Res. 2012, 8: 47.10.1186/1746-6148-8-47353759522546414Search in Google Scholar

42. Caswell JL, Williams KJ: Respiratory System in Jubb, Kennedy & Palmer’s Pathology of Domestic Animals: Volume 2 (Sixth Edition), 2016, 5: 465-59110.1016/B978-0-7020-5318-4.00011-5Search in Google Scholar

43. Pijoan C, Trigo E.: Bacterial adhesion to mucosal surfaces with special reference to Pasteurella multocida isolates from atrophic rhinitis. Can J Vet Res 1990, 54:516–521.Search in Google Scholar

44. Gottschalk M and Taylor DJ: Actinobacillus pleuropneumoniae. In: Diseases of Swine, ed. Straw BE, Zimmerman JJ, D’Allaire S, and Taylor DJ, 9th ed., Ames, IA: Blackwell Publishing, 2006, 33: 563–577.Search in Google Scholar

45. Caswell JL, Williams KJ: Respiratory System in Jubb, Kennedy & Palmer’s Pathology of Domestic Animals: Volume 2 (Sixth Edition), 2016, 5: 465-591.10.1016/B978-0-7020-5318-4.00011-5Search in Google Scholar

46. Frank RK, Chengappa MM, Oberst RD: Pleuropneumonia caused by Actinobacillus pleuropneumoniae biotype 2 in growing and finishing pigs. J Vet Diagn Invest 1992, 4:270–278.10.1177/104063879200400308Search in Google Scholar

47. Sassu EL, Bosse JT, Tobias TJ, Gottschalk M, Langford PR, Hennig-Pauka I: Update on Actinobacillus pleuropneumoniae-knowledge, gaps and challenges. Transbound Emerg Dis. 2018, 65 (Suppl.1):72-90.10.1111/tbed.12739Search in Google Scholar

48. Bosse JT, Janson H, Sheehan BJ, Beddek AJ, Rycroft N, Kroll JS, Langford PR: Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection. Microbes and Infection 2002, 4:225-235.10.1016/S1286-4579(01)01534-9Search in Google Scholar

49. Čobanović N, Jamnikar-Ciglenečki U, Kirbiš A, Križman M, Štukelj M, Karabasil N: Impact of various housing conditions onthe occurrence of pathological lesionsin slaughtered pigs. Veterinarski glasnik, 2019, 73(1): 17-29.10.2298/VETGL190318010CSearch in Google Scholar

50. Tobias TJ, Bouma A, van den Broek J, van Nes A, Daemen AJJM, Wagenaar JA, Stegeman JA, Klinkenberg D. Transmission of Actinobacillus pleuropneumoniae among weaned piglets on endemically infected farms. Prev. Vet. Med. 2014, 117:207-214.10.1016/j.prevetmed.2014.07.01725156946Search in Google Scholar

51. Klinkenberg D,Tobias TJ, Bouma A, van Leengoed LAMG, Stegeman JA: Simulation study of the mechanisms underlying outbreaks of clinical disease caused by Actinobacillus pleuropneumoniae in finishing pigs. Vet J 2014, 202 (1): 99-105.10.1016/j.tvjl.2014.06.01525155305Search in Google Scholar

52. VanAlstine WG: Respiratory system. In: Zimmerman, J.J., Karriker, L.A., Ramirez, A., Schwartz, K.J., Stevenson, G.W. (Eds.), Diseases of Swine, tenth ed. Ames, Iowa: Iowa State University Press, 2012,348–362.Search in Google Scholar

53. Pijoan C: Pneumonic Pasteurellosis. In: Diseases of Swine, ed. Straw BE, Zimmerman JJ, D’Allaire S, and Taylor DJ, 9th ed., Ames, IA: Blackwell Publishing, 2006, 33: 719–727.Search in Google Scholar

54. Pors MSH, Bisgaard M, Jensen HE: Occurrence and associated lesions of Pasteurella multocida in porcine bronchopneumonia. Vet. Microbiol. 2011, 150:160–166.10.1016/j.vetmic.2011.01.00521296510Search in Google Scholar

55. Register KB, Brockmeier SL, de Jong MF, Pijoan C: Pasteurellosis. In: Disease of Swine, ed.Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW, 10th ed., Ames, IA: Blackwell Publishing, 2012, 58: 798-810.Search in Google Scholar

56. Chung WB, Backstrom LR and Collins MT: Experimental model of swine pneumonic pasteurellosis using crude Actinobacillus pleuropneumoniae cytotoxin and Pasteurella multocida given endobronchially. Canadian Journal of Veterinary Research 1994, 58: 25–30.Search in Google Scholar

57. Tigga M, Ghosh R.C, Malik P, Choudhary B.K, Tigga P, Nagar D.K.: Isolation, characterization, antibiogram and pathology of Pasteurella multocida isolated from pigs. Vet. World. 2014, 7(5): 363–368.Search in Google Scholar

58. Rapp-Gabrielson VJ, Oliveira SR, Pijoan C: Haemophilus parasuis. In: Diseases of Swine, ed. Straw BE, Zimmerman JJ, D’Allaire S, and Taylor DJ, 9th ed., Ames, IA: Blackwell Publishing, 2006, 33: 681–691.Search in Google Scholar

59. Macedo N, Rovira A and Torremorell M. Haemophilus parasuis: infection, immunity and enrofloxacin. Vet Res 2015, 46:128.10.1186/s13567-015-0263-3462587326511717Search in Google Scholar

60. Oliveira S, Pijoan C: Haemophilus parasuis: new trends on diagnosis, epidemiology and control. Vet. Microbiol. 2004, 99:1-12.10.1016/j.vetmic.2003.12.00115019107Search in Google Scholar

61. Zhang B, TangC, Liao M, Yue H. Update on the pathogenesis of Haemophilus parasuis infection and virulence factors. Vet Microbiol. 2014, 168:1-7.10.1016/j.vetmic.2013.07.02723972951Search in Google Scholar

62. Galofre-Mila N, Correa-Fiz F, Lacouture S, Gottschalk M, Strutzberg-Minder K, Bensaid A, Pina-Pedrero S. Aragon V: A robust pCR for the differentiation of potential virulent strains of Haemophilus parasuis. BMC Vet. Res. 2017, 13:124.10.1186/s12917-017-1041-4542295028482900Search in Google Scholar

63. Correa-Fiz F, Fraile L, Aragon V: Piglet nasal microbiota at weaning may influence the development of Glasser disease during rearing period. BMC Genomics 2016, 17: 404.10.1186/s12864-016-2700-8488105127230662Search in Google Scholar

64. Aleksic-Kovacevic S, Vucicevic I, Jovanovic I, Prodanov-Radulovic J: Epizootiological and morphological character of current respiratory infections of pigs in the Republic of Serbia. Proceeding of 30th seminar of veterinarians of Serbia, Zlatibor 2019, 37-48.Search in Google Scholar

65. Aragon V, Segales J, Oliveira S. Glässer’s Disease. In: Disease of Swine, ed. Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW, 10th ed., Ames, IA: Blackwell Publishing, 2012, 55: 760-768.Search in Google Scholar

66. Palzer A, Ritzmann M, Wolf G, Heinritzi K: Associations between pathogens in healthy pigs and pigs with pneumonia. Vet. Rec. 2008, 162:267-271.10.1136/vr.162.9.26718310558Search in Google Scholar

67. Savic B, Ivetic V, Milicevic V, Pavlovic I, Zutic M, Gagrcin M: Genetic diversity of Mycoplasma hyopneumoniae isolates from conventional farrow-to-finish pig farms in Serbia. Acta Vet. Hung. 2010, 58:297-308.10.1556/avet.58.2010.3.3Search in Google Scholar

68. Sibila M, Pieters M, Molitor T, Maes D, Haesebrouck F, Segales J: Current perspectives on the diagnosis and epidemiology of Mycoplasma hyopneumoniae infection. Vet J 2009. 181:221–231.10.1016/j.tvjl.2008.02.020711080518396428Search in Google Scholar

69. Thacker EL, Minion FC: Mycoplasmosis. In: Zimmerman JJ, Karriker LA, Schwartz KJ, (eds.), Disease of Swine, 10th ed. Wiley-Blackwell, Oxford, UK, 2012, 779-797.Search in Google Scholar

70. Thacker EL: Mycoplasmal Diseases. In: Diseases of Swine, ed. Straw BE, Zimmerman JJ, D’Allaire S, and Taylor DJ, 9th ed., Ames, IA: Blackwell Publishing, 2006, 33: 701–718.Search in Google Scholar

71. García-Morante B, Segalés J, Fraile L, Pérez de Rozas A, Maiti H, Coll T,Sibila M: Assessment of Mycoplasma hyopneumoniae-Induced pneumonia using different lung lesion scoring systems: A comparative review. Journal of Comparative Pathology 2016, 154:125–134.10.1016/j.jcpa.2015.11.00326774274Search in Google Scholar

72. Woolley LK, Fell S, Gonsalves JR, Walker MJ, Djordjevic SP, Jenkins C, Eamens GJ: Evaluation of clinical, histological and immunological changes and qPCR detection of Mycoplasma hyopneumoniae in tissues during the early stages of mycoplasmal pneumonia in pigs after experimental challenge with two field isolates. Vet. Microbiol. 2012, 161:186 – 195.10.1016/j.vetmic.2012.07.02522863144Search in Google Scholar

73. Sarradell J, Andrada M, Ramirez AS, Fernandez A, Gomez-Villamandos JC, Jover A, Lorenzo H, Herraez P, Rodriguez F: A Morphologic and Immunohistochemical Study of the Bronchus-associated Lymphoid Tissue of Pigs Naturally Infected with Mycoplasma hyopneumoniae. Vet Pathol 2003, 40:395–404.10.1354/vp.40-4-39512824511Search in Google Scholar

74. Vangroenweghe FACJ, Labarque GG, Piepers S, Strutzberg –Minder K, Maes D: Mycoplasma hyopneumoniae infections in peri-weaned and post-weaned pigs in Belgium and THE Netherlands: Prevalence and associations with climatic conditions. Vet J 2015, 205:93-97.10.1016/j.tvjl.2015.03.02825981930Search in Google Scholar

75. Fraile L, Alegre A, López-Jiménez R, Nofrarías M, Segalés J: Risk factors associated with pleuritis and cranio-ventral pulmonary consolidation in slaughter-aged pigs. Vet J 2010, 184: 326–333.10.1016/j.tvjl.2009.03.02919527939Search in Google Scholar

76. Meyns T, Van Steelant J, Rolly E, Dewulf J, Haesebrouck F, Maes D: A cross-sectional study of risk factors associated with pulmonary lesions in pigs at slaughter. Vet. J. 2011,187:388–392.10.1016/j.tvjl.2009.12.02720122861Search in Google Scholar

77. Nathues H, Spergser J, Rosengarten R, Kreienbrock L, grosse Beilage E. Value of the clinical examination in diagnosing enzootic pneumonia in fattening pigs. Vet J 2012,193:443-447.10.1016/j.tvjl.2012.01.01322342214Search in Google Scholar

78. Opriessnig T, Thaker EL, Yu S, Fenaux M, Meng XJ, Halbur PG: Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Vet. Pathol. 2004, 41:624-640.10.1354/vp.41-6-62415557072Search in Google Scholar

79. Otake S, Dee S, Corzo C, Oliviera S, Deen J: Long-distance airborne transport of infectious PRRSV and Mycoplasma hyopneumoniae from a swine population infected with multiple viral variants. Vet. Microbiol. 2010, 145(3-4):198-208.10.1016/j.vetmic.2010.03.02820418029Search in Google Scholar

80. Yeske P, Valeris-Chacin Rm Singer RS, Pieters M: Survival analysis of two Mycoplasma hyopneumoniae eradication methods, Prev. Vet. Med. 2020, 174:104811.10.1016/j.prevetmed.2019.10481131710945Search in Google Scholar

81. Balka G, Podgórska K, Singh Brar M, Bálint A, Cadar D, Celer V, Dénes L, Dirbakova Z, Jedryczko A, Márton L, Novosel D, Petrović T, Sirakov I, Szalay D, Toplak I, Chi-Ching Leung F, Stadejek T: Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region. Scientific Reports 2018, 8:7811.10.1038/s41598-018-26036-w595808029773820Search in Google Scholar

82. Došen R, Prodanov-Radulović J, Pušić I, Gagrčin M: Biosecurity measures in villages and rural households. Proceedings, International Conference prevention of Classical Swine Fever in the Border Region Croatia - Serbia (STOP-KKS), Novi Sad, 2012, 306-314.Search in Google Scholar

83. Montaner-Tarbes S, del Portillo A, Montoya M, Fraile L: Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV). Front. Vet. Sci. 2019, 6:38.10.3389/fvets.2019.00038639186530842948Search in Google Scholar

84. Zimmerman J, Benfield DA, Murtaugh MP, Osorio F, Stevenson GW, Torremorell M: Porcine Reproductive and Respiratory Syndrome Virus (Porcine Arterivirus). In: Diseases of Swine, ed. Straw BE, Zimmerman JJ, D’Allaire S, and Taylor DJ, 9th ed., Ames, IA: Blackwell Publishing, 2006, 33: 387–419.Search in Google Scholar

85. Aleksić-Kovačević S: Respiratorni system. U: Jovanović M, AleksićKovačević S, Knežević M, Specijalna veterinarska patologija, Udruženje veterinarskih patologa Srbije, Beograd, Srbija, 2019, 145-184.Search in Google Scholar

86. Wagner J, Kneucker A, Liebler-Tenorio E, Fachinger V, Glaser M, Pesch S, Murtaugh MP, Reinhold P: Respiratory function and pulmonary lesions in pigs infected with porcine reproductive and respiratory syndrome virus. Vet J 2010, 18:310–319.10.1016/j.tvjl.2009.12.022712826520089425Search in Google Scholar

87. Neumann EJ, Kliebenstein JB, Jhnson CD, Mabry JW, Bush EJ, Seitzinger AH: Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J Am Vet Med Assoc 2005, 227: 385-92.10.2460/javma.2005.227.38516121604Search in Google Scholar

88. Zimmerman JJ, Benfield DA, Dee SA, Murtaugh MP, Stadejek T, Stevenson GW,Torremorell M: Porcine Reproductive and Respiratory Syndrome Virus (Porcine Arterivirus). In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW(Eds.), Diseases of Swine, 10th ed. Iowa State, Ames: Wiley-Blackwell, 2012, 461-486.Search in Google Scholar

89. Jeong J, Kim S, Park KH, Kang I, Park S-J, Park C: Evaluation of the effect of a porcine reproductive and respiratory syndrome (PRRS) modified-live virus vaccine on sow reproductive performance in endemic PRRS farms. Vet Microbiol 2017, 208:47-52.10.1016/j.vetmic.2017.07.01628888648Search in Google Scholar

90. Fablet C, Dorenlor V, Eono F, Eveno E, Jolly JP, Portier F, Bidan F, Madec F, Rose N: Noninfectious factors associated with pneumonia and pleuritis in slaughtered pigs from 143 farrow-to-finish pig farms Prev. Vet. Med. 2012, 104:271–280.10.1016/j.prevetmed.2011.11.01222196500Search in Google Scholar

91. Pileri E, Gibert E, Soldevila F, Garcia-Saenz A, Pujols J, Diaz I, Darwich l, Casal J, Martin M, Mateu E: Vaccination with genotype 1 modified live vaccine against porcine reproductive and respiratory syndrome virus significantly reduces viraemia, viral shedding and transmission of the virus in a quasi-natural experimental model. Vet Microbiol 2015, 175:7-16.10.1016/j.vetmic.2014.11.00725439650Search in Google Scholar

92. Olsen CW, Brown IH, Easterday BC, Van Reeth K: Swine Influenza. In: Diseases of Swine, ed. Straw BE, Zimmerman JJ, D’Allaire S, and Taylor DJ, 9th ed., Ames, IA: Blackwell Publishing, 2006, 33: 469-483.Search in Google Scholar

93. Sreta D, Kedkovid R, Tuamsang S, Kitikoon P, Thanawongnuwech R: Pathogenesis of swine influenza virus (Thai isolates) in weanling pigs: an experimental trial, Virol. J. 2009, 6:34.10.1186/1743-422X-6-34267808819317918Search in Google Scholar

94. Brown IH: Influenza A Viruses in Pigs in Europe. In: Trends in Emerging Viral Infections of Swine. Ed by Morilla A, Yoon K-Y, Zimmerman JJ. Iowa State: Iowa University Press 2002, 29-36.10.1002/9780470376812.ch2bSearch in Google Scholar

95. Van Reeth K, Brown IH, and Olsen CW: Influenza virus. In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW (Eds.), Diseases of Swine, 10th ed. Iowa State: Wiley-Blackwell, Ames 2012, 40:557-573.Search in Google Scholar

96. Yoon K-J, Janke BH: Swine Influenza: Etiology, Epidemiology and Diagnosis. In: Trends in Emerging Viral Infections of Swine. Ed by Morilla A, Yoon K-Y, Zimmerman JJ. Iowa State: University Press 2002, 23-28.10.1002/9780470376812.ch2aSearch in Google Scholar

97. Božić B, Polaček V, Vučićević I, Vidanović D, Vasković N, Prodanov-Radulović J, Aleksić-Kovačević S: Morphological differences of pancreatic lesions in mute swans and hens naturally infected with highly pathogenic avian influenza virus H5N8. Acta Veterinaria-Beograd 2018, 68 (2): 217-223.10.2478/acve-2018-0018Search in Google Scholar

98. Bourret V. Avian influenza viruses in pigs: An overview. The Veterinary Journal 2018, 239:7-14.10.1016/j.tvjl.2018.07.00530197112Search in Google Scholar

99. Loeffen WLA, Hunneman WA, Quak J, Verheijden JHM, Stegeman JA: Population dynamics of swine influenza virus in farrow-to-finish and specialised finishing herds in the Netherlands. Vet Microbiol 2009, 137: 45-50.10.1016/j.vetmic.2009.01.00419181461Search in Google Scholar

100. Segalés J, Allan GM, Domingo M: Porcine Circovirus Diseases. In: Diseases of Swine, ed. Straw BE, Zimmerman JJ, D’Allaire S, and Taylor DJ, 9th ed., Ames, IA: Blackwell Publishing, 2006, 33: 299-309.Search in Google Scholar

101. Savic B, Milicevic V, Jakic-Dimic D, Bojkovski J, Prodanovic R, Kureljusic B, Potkonjak A: Genetic characterization and phylogenetic analysis of porcine circovirus type 2 (PCV2) in Serbia. Arch Virol 2012, 157:21–28.10.1007/s00705-011-1130-921964944Search in Google Scholar

102. Baekbo P, Kristensen CS, Larsen LE: Porcine Circovirus Diseases: A review of PMWS. Transboundary and Emerging Diseases 2012, 59 (Suppl.1):60-67.10.1111/j.1865-1682.2011.01288.x22252114Search in Google Scholar

103. Opriessnig T and Halbur PG: Concurrent infections are important for expression of porcine circovirus associated disease. Virus Research 2012, 164:20–32.10.1016/j.virusres.2011.09.014711443221959087Search in Google Scholar

104. Ouyang T, Zhang X, Liu X, Ren L: Co-Infection of Swine with Porcine Circovirus Type 2 and Other Swine Viruses. Viruses 2019, 11:185.10.3390/v11020185641002930795620Search in Google Scholar

105. Pejsak ZK, Truszczynski MJ: Aujeszky’s Disease (Pseudorabies). In: Diseases of Swine, ed. Straw BE, Zimmerman JJ, D’Allaire S, and Taylor DJ, 9th ed., Ames, IA: Blackwell Publishing, 2006, 33: 419-435.Search in Google Scholar

106. Sun Y, Luo Y, Wang C-H, Yuan J, Li n, Song K, Qiu H-J: Control of swine pseudorabies in china: Opportunities and limitations. Vet Microbiol 2016, 183:119-124.10.1016/j.vetmic.2015.12.00826790944Search in Google Scholar

107. Mettenleiter TC: Aujeszkys disease (pseudorabies) virus: the virus and molecular pathogenesis-state of art. Vet Res. 2000, 31:99-115.10.1051/vetres:2000110Search in Google Scholar

108. Pomeranz LE, Reynold AE, Hengartner CJ: Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine. Microbiol. Mol. Biol. Rev. 2005, 69:462-500.10.1128/MMBR.69.3.462-500.2005119780616148307Search in Google Scholar

109. Muller T, Hahn EC, Tottewitz F, Kramer M, Klupp BG, Mettenleiter TC, Freuling C: Pseudorabies virus in wild swine: a global perspective. Arch. Virol. 2011, 156:1691-170510.1007/s00705-011-1080-221837416Search in Google Scholar

110. Rosales C and Morilla A: Epidemiological Pattern of Aujeszky Disease in a Hyperendemic Area of Mexico. In: Trends in Emerging Viral Infections of Swine. Ed by Morilla A, Yoon K-Y, Zimmerman JJ. Iowa: Iowa State University Press. 2002,217-220.10.1002/9780470376812.ch7bSearch in Google Scholar

111. Janković Lj, Drašković V, Pintarič Š, Mirilović M, Đurić S, Tajdić N, Teodorović R: Rodent pest control. Veterinarski Glasnik. 2019, 73 (2): 85-99.10.2298/VETGL190507020JSearch in Google Scholar

112. Milićević V, Kureljušić B, Maksimović Zorić J, Savić B, Stanojević S, Milakara E: First occurence of african swine fever in Serbia. Acta Veterinaria-Beograd 2019, 69 (4): 443-449.10.2478/acve-2019-0038Search in Google Scholar

113. Delić N, Drašković V, Stevanović J, Savić B, Lakić N, Bošnjak-Neumüller J, Stanimirović Z: The efficacy of two phytogenic feed additives in the control of swine dysentery. Acta Veterinaria-Beograd 2018, 68 (2), 178-189.10.2478/acve-2018-0016Search in Google Scholar

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