[1. Niemiec BA: Periodontal Disease. Topics in Companion. Animal Medicine 2008, 23(2): 72-8010.1053/j.tcam.2008.02.00318482707]Search in Google Scholar
[2. Guentsch A, Preshaw PM, Bremer-Streck S, Klinger G, Glockmann E, Sigusch BW: Lipid peroxidation and antioxidant activity in saliva of neutrophils as a possible model for the emergence of periodontitis. Oral Dis 2008, 12(4):345-352.10.1007/s00784-008-0202-z18509684]Search in Google Scholar
[3. Kouki MI, Papadimitriou SA, Kazakos GM, Savas I, Bitchava D: Periodontal disease as a potential factor for systemic inflammatory response in the dog. J Vet Dent 2013, 30(1): 26-29.10.1177/08987564130300010323757822]Search in Google Scholar
[4. Albuquerque C, Morinha F, Requicha J, Martins T, Dias I, Guedes-Pinto H, Bastos E, Viegas C: Canine periodontitis: The dog as an important model for periodontal studies. Vet J. 2012, 191: 299-305.10.1016/j.tvjl.2011.08.01721940182]Search in Google Scholar
[5. Riggio MP, Lennon A, Taylor DJ, Bennett D: Molecular identification of bacteria associated with canine periodontal disease. Vet Microbiol. 2011, 150(3-4):394-400.10.1016/j.vetmic.2011.03.00121489726]Search in Google Scholar
[6. Gioso MA, Carvalho VG: Metodos Preventivos para a manutenção da boa saúde bucal em cães e gatos. Clinica Veterinária 2004, 52:68-76.]Search in Google Scholar
[7. Genco RJ: Host responses in periodontal diseases: current concepts. J. Periodontol 1992, 63(4): 338-355.10.1902/jop.1992.63.4s.3381573548]Search in Google Scholar
[8. Liu YCG, Lerner UH, Teng YTA: Cytokine responses against periodontal infection: protective and destructive roles. Periodontol 2000, 52(1):163-206.10.1111/j.1600-0757.2009.00321.x20017801]Search in Google Scholar
[9. Zhang S, Barros SP, Niculescu MD, Moretti AJ, Preisser JS, Offenbacher, S: Alteration of PTGS2 Promoter Methylation in chronic Periodontitis. J Dent Res 2010, 89(2): 133-137.10.1177/0022034509356512306512220042743]Search in Google Scholar
[10. Kayal, RA: The role of osteoimmunology in periodontal disease. Biomed Res Int 2013, doi: 10.1155/2013/639368.10.1155/2013/639368378930724151615]Search in Google Scholar
[11. Amano A: Host–parasite interactions in periodontitis: microbial pathogenicity and innate immunity. Periodontol 2010, 54: 9-14.10.1111/j.1600-0757.2010.00376.x20712630]Search in Google Scholar
[12. Kishimoto T, Akira S, Narazaki M, Taga T: Interleukin-6 family of cytokines and Gp130. Blood 1995, 86(4): 1243-1254.10.1182/blood.V86.4.1243.bloodjournal8641243]Search in Google Scholar
[13. Matsuki Y, Yamamoto T, Hara K: Detection of inflammatory cytokine messenger-RNA (Messenger RNA)- expressing cells in human inflamed gingiva by combined in situ hybridization and immunohistochemistry. Immunology 1992, 76(1): 42-47.]Search in Google Scholar
[14. Loos BG: Systemic markers of inflammation in periodontitis. J Periodontol 2005, 76(11): 2106-2115.10.1902/jop.2005.76.11-S.2106]Search in Google Scholar
[15. Blum A, Front E, Peleg A: Periodontal care may improve systemic inflammation. Clin Invest Med 2007, 13(30): 114-117.10.25011/cim.v30i3.1079]Search in Google Scholar
[16. Buttke TM, Shipper G, Delano EO, Trope M: C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. J Endod 2005, 10:728-32.10.1097/01.don.0000158008.34623.6c]Search in Google Scholar
[17. Negro VB, Ciappesoni JL, Sorbello C, Rodriguez D, Juarez M, Mas J, Hernandez SZ: Periodontal disease in dogs: correlation between degree of disease, blood parameters, and systemic inflammatory response, and its response to treatment. 2015, 24th ECVD.]Search in Google Scholar
[18. Yu G, Yu Y, Li YN, Shu R: Effect of periodontitis on susceptibility to atrial fibrillation in an animal model. J Electrocardiol 2010, 43(4):59-66.10.1016/j.jelectrocard.2009.12.002]Search in Google Scholar
[19. Chistiakov DA, Orekhov AN, Bobryshev YV: Links between atherosclerotic and periodontal disease. Exp. Mol. Pathol 2016, 100(1):220-235.10.1016/j.yexmp.2016.01.006]Search in Google Scholar
[20. Sulaiman, A.E, Shehadeh RM: Assessment of total antioxidant capacity and the use of vitamin C in the treatment of non-smokers with chronic periodontitis. J. Periodontol 2010, 81(11): 1547-1554.10.1902/jop.2010.100173]Search in Google Scholar
[21. Sies H: Oxidative stress: oxidants and antioxidants. Exp. Physiol. 1997, 82(2): 291-295.10.1113/expphysiol.1997.sp004024]Search in Google Scholar
[22. Panjamurthy K, Manoharan S, Ramachandran CR: Lipid peroxidation and antioxidant status in patients with periodontitis. Cell. Mol. Biol. Lett 2005, 10(2): 255-264.]Search in Google Scholar
[23. Canakci CF, Cicek Y, Yildirim A, Sezer U, Canakci V: Increased levels of 8-hydroxydeoxyguanosine and malondialdehyde and its relationship with antioxidant enzymes in saliva of periodontitis patients. Eur. J. Dent 2009, 3(2):100-106.10.1055/s-0039-1697415]Search in Google Scholar
[24. Ahmadi-Motamayel F, Goodarzi TM, Jamshidi Z, Kebriaei R: Evaluation of Salivary and Serum Antioxidant and Oxidative Stress Statuses in Patients with Chronic Periodontitis: A Case-Control Study, Front Physiol 2017, 31(8):189.10.3389/fphys.2017.00189]Search in Google Scholar
[25. Kahn CM, Line S: Digestive System, Dentistry: Periodontal Diseases in Small Animals. In, Kahn CM, Line S (Eds): The Merck Veterinary Manual. 9th edn., 143-147, Merck and Co. Inc Merial LTD, USA, 2005.]Search in Google Scholar
[26. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Labor Clin Med. 1967, 70:158-169.]Search in Google Scholar
[27. Sun Y, Oberley LW, Li Y: A simple method for clinical assay of superoxide dismutase. Clin Nephrol 1988, 53: 9-17.]Search in Google Scholar
[28. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Ann Biochem. 1979, 95: 351-358.10.1016/0003-2697(79)90738-3]Search in Google Scholar
[29. Kumar BP, Khaitan T, Ramaswamy P, Sreenivasulu P, Uday G, Velugubantla RG: Association of chronic periodontitis with white blood cell and platelet count – A Case control study, J Clin Exp Dent 2014, 3:214-217.10.4317/jced.51292413484725136419]Search in Google Scholar
[30. Rawlinson JE, Goldstein RE, Reiter AM, Attwater DZ, Harvey CE: Association of periodontal disease with systemic health indices in dogs and the systemic response to treatment of periodontal disease. J Am Vet Med Assoc 2011, 238(5):601-609.10.2460/javma.238.5.60121355802]Search in Google Scholar
[31. Petelin M, Pavlica Z, Ivanusa TS, Sentjurc M, Skaleric U: Local delivery of liposome encapsulated superoxide dismutase and catalase suppress periodontal inflammation in beagles. J. Clin. Periodontol 2000, 27(12):918-925.10.1034/j.1600-051x.2000.027012918.x11140559]Search in Google Scholar
[32. Sakallıoğlu U, Aliyev E, Eren Z, Akşimşek G, Keskiner I, Yavuz Ü: Reactive oxygen species scavenging activity during periodontal mucoperiosteal healing: An experimental study in dogs, Arch Oral Biol. 2005, 50(12):1040-1046.10.1016/j.archoralbio.2005.03.01215939395]Search in Google Scholar
[33. Li W, Huang B, Liu K,Hou J, Meng H: Upregulated leptin in periodontitis promotes ınflammatory cytokine expression in periodontal ligament cells, J. Periodontol 2015, 86(7): 917-926.10.1902/jop.2015.15003025879793]Search in Google Scholar
[34. Oliveira RR, Novaes AB, Garlet PG, Souza FR, Taba M, Sato S, Souza SLS, Palioto BD, Grisi MFM, Feres M: The effect of a single episode of antimicrobial photodynamic therapy in the treatment of experimental periodontitis. Microbiological profile and cytokine pattern in the dog mandible, Lasers Med Sci 2011, 26(3):359-367.10.1007/s10103-010-0864-z21086009]Search in Google Scholar
[35. Dong M, Yu X, Chena W, Guo Z, Sui L, Xu Y, Shang Y, Niu W, Kong Y: Osteopontin promotes bone destruction in periapical periodontitis by activating the NF-κB pathway, Cell Physiol Biochem. 2018; 49(3):884-898.10.1159/00049321930184545]Search in Google Scholar
[36. Christgau M, Caffese GR, Schmalz G, D’Souza NR: Extracellular matrix expression and periodontal wound-healing dynamics following guided tissue regeneration therapy in canine furcation defects, J Clin Periodontol. 2007, 34(8):691-708.10.1111/j.1600-051X.2007.01097.x17590157]Search in Google Scholar
[37. Tyler RD, Cowell RL, Meinkoth JH: Disorders and laboratory evaluation. In: Veterinary Clinical Pathology Secrets. Elsevier Mosby, Missouri, USA. 2004, 51-60.10.1016/B978-1-56053-633-8.50014-0]Search in Google Scholar
[38. Silva MR, Matono D, Bosko AM, Baptistiolli L, Torrecilha RBP, Ciarlini PC: Oxidative stress in dogs with periodontal disease: comparison of plasmatic and salivary biomarkers, Arq. Bras. Med. Vet. Zootec 2018, 70(5):1369-1377.10.1590/1678-4162-9246]Search in Google Scholar