<abstract xmlns="http://www.w3.org/1999/xhtml"><p>To evaluate the efficiency of the probiotic strain <italic>Lactobacillus plantarum</italic> LS/07 in dextran sulphate sodium (DSS) induced acute colitis selected biochemical (activity of β-glucuronidase), microbiological (counts of lactobacilli and coliforms), and immunological (IL-6, IL-8, IL-13, NF-κB, MPO) parameters were assessed. Sprague-Dawley rats were divided into groups: Control, Acute colitis, and Probiotic. Acute colitis was induced using 5% DSS in drinking water for 7d. DSS induced an inflammatory process in the colonic tissue, increased the activity of β-glucuronidase (p&lt;0.001), increased the counts of coliform bacteria and decreased lactobacilli counts (p&lt;0.05), and activated the production of the measured parameters (NF-κB, MPO, IL-6, IL-8) except of IL-13. <italic>Lactobacillus plantarum</italic> LS/07 in the diet alleviated the DSS induced inflammatory process by inhibiting the production of IL-6, IL-8, the activities of NF-κB and MPO, and stimulated the production of IL-13. The probiotic reduced the activity of β-glucuronidase (p&lt;0.05), increased lactobacilli counts and decreased coliform bacteria. These results indicate that dietary intake of <italic>Lactobacillus plantarum</italic> LS/07 suppressed the expression of markers playing an important role in the inflammatory process. We conclude that the anti-inflammatory properties of <italic>Lactobacillus plantarum</italic> LS/07 makes its suitable for the prevention or treatment of colitis.</p></abstract>

To evaluate the efficiency of the probiotic strain Lactobacillus plantarum LS/07 in dextran sulphate sodium (DSS) induced acute colitis selected biochemical (activity of β-glucuronidase), microbiological (counts of lactobacilli and coliforms), and immunological (IL-6, IL-8, IL-13, NF-κB, MPO) parameters were assessed. Sprague-Dawley rats were divided into groups: Control, Acute colitis, and Probiotic. Acute colitis was induced using 5% DSS in drinking water for 7d. DSS induced an inflammatory process in the colonic tissue, increased the activity of β-glucuronidase (p<0.001), increased the counts of coliform bacteria and decreased lactobacilli counts (p<0.05), and activated the production of the measured parameters (NF-κB, MPO, IL-6, IL-8) except of IL-13. Lactobacillus plantarum LS/07 in the diet alleviated the DSS induced inflammatory process by inhibiting the production of IL-6, IL-8, the activities of NF-κB and MPO, and stimulated the production of IL-13. The probiotic reduced the activity of β-glucuronidase (p<0.05), increased lactobacilli counts and decreased coliform bacteria. These results indicate that dietary intake of Lactobacillus plantarum LS/07 suppressed the expression of markers playing an important role in the inflammatory process. We conclude that the anti-inflammatory properties of Lactobacillus plantarum LS/07 makes its suitable for the prevention or treatment of colitis.

Anti-inflammatory potential of <italic>Lactobacillus plantarum</italic> LS/07 in acute colitis in rats

Institute of Experimental Medicine, Medical Faculty

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Anti-inflammatory potential of  LS/07 in acute colitis in rats

To evaluate the efficiency of the probiotic strain Lactobacillus plantarum LS/07 in dextran sulphate sodium (DSS) induced acute colitis selected biochemical...

Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats

Published Online: Mar 27, 2018

Page range: 55 - 64

Received: Jun 14, 2017

Accepted: Nov 13, 2017

DOI: https://doi.org/10.2478/acve-2018-0005

Keywords
Sprague-Dawley rats, Colitis, Inflammation, LS/07

© 2018 Hijová Emília et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats

Published Online: Mar 27, 2018

Page range: 55 - 64

Received: Jun 14, 2017

Accepted: Nov 13, 2017

DOI: https://doi.org/10.2478/acve-2018-0005

KeywordsSprague-Dawley rats, Colitis, Inflammation, LS/07

© 2018 Hijová Emília et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Sprague-Dawley rats, Colitis, Inflammation, LS/07