<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before finishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after extirpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confirmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that Adipograft Ra 1vk 7/350 can be a turning point in the development of vascular prostheses, due to its patency and quick healing.</p></abstract>

Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before finishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after extirpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confirmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that Adipograft Ra 1vk 7/350 can be a turning point in the development of vascular prostheses, due to its patency and quick healing.

Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep

Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic

Department of Preventive Medicine, Faculty of Medicine, Masaryk University, Brno, Czech Republic

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and...

Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep

Published Online: Dec 30, 2014

Page range: 426 - 437

Received: Mar 29, 2014

Accepted: Sep 09, 2014

DOI: https://doi.org/10.2478/acve-2014-0040

Keywords
adiponectin, experimental surgery, pre-clinical trial, vascular prosthesis.

© by Podlaha Jiří

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep

Published Online: Dec 30, 2014

Page range: 426 - 437

Received: Mar 29, 2014

Accepted: Sep 09, 2014

DOI: https://doi.org/10.2478/acve-2014-0040

Keywordsadiponectin, experimental surgery, pre-clinical trial, vascular prosthesis.

© by Podlaha Jiří

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
adiponectin, experimental surgery, pre-clinical trial, vascular prosthesis.