<abstract xmlns="http://www.w3.org/1999/xhtml"><p> This pilot-study evaluated the toxicity and safety profile of two herbal products Souroubea spp Botanical Blend (SSBB) and Platanus Tree Bark (PTB) after oral administration to dogs at elevated doses for 28 days. SSBB and PTB botanicals are the major active ingredients of Sin Susto™, a novel natural product for the treatment of anxiety in dogs. Three healthy female dogs were administered elevated doses of either SSBB, PTB or a placebo and then monitored for the occurrence of any systemic and local adverse events. Data from this pilot-study revealed that SSBB and PTB had no untoward effects on the health of dogs and were deemed safe which enabled the design and execution of a larger controlled target safety and toxicology study for Sin Susto™.</p></abstract>

This pilot-study evaluated the toxicity and safety profile of two herbal products Souroubea spp Botanical Blend (SSBB) and Platanus Tree Bark (PTB) after oral administration to dogs at elevated doses for 28 days. SSBB and PTB botanicals are the major active ingredients of Sin Susto™, a novel natural product for the treatment of anxiety in dogs. Three healthy female dogs were administered elevated doses of either SSBB, PTB or a placebo and then monitored for the occurrence of any systemic and local adverse events. Data from this pilot-study revealed that SSBB and PTB had no untoward effects on the health of dogs and were deemed safe which enabled the design and execution of a larger controlled target safety and toxicology study for Sin Susto™.

Clinical Observations and Safety Profile of Oral Herbal Products, Souroubea and Platanus Spp; a Pilot-Toxicology Study in Dogs

Veterinary Clinic Bethel Medical, San Jose, Costa Rica

Bioniche Animal Health, Belleville, Ontario, Canada

Universidad Nacional, Heredia, Costa Rica

University of Ottawa, Ottawa, Ontario, Canada

Acta Veterinaria

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This pilot-study evaluated the toxicity and safety profile of two herbal products Souroubea spp Botanical Blend (SSBB) and Platanus Tree Bark (PTB) after oral...

Clinical Observations and Safety Profile of Oral Herbal Products, Souroubea and Platanus Spp; a Pilot-Toxicology Study in Dogs

Published Online: Jun 17, 2014

Page range: 269 - 275

Received: Mar 20, 2014

Accepted: Apr 07, 2014

DOI: https://doi.org/10.2478/acve-2014-0025

Keywords
anxiety, dogs, Souroubea spp, Platanus, Sin Susto™

© by John T. Arnason

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Clinical Observations and Safety Profile of Oral Herbal Products, Souroubea and Platanus Spp; a Pilot-Toxicology Study in Dogs

Published Online: Jun 17, 2014

Page range: 269 - 275

Received: Mar 20, 2014

Accepted: Apr 07, 2014

DOI: https://doi.org/10.2478/acve-2014-0025

Keywordsanxiety, dogs, Souroubea spp, Platanus, Sin Susto™

© by John T. Arnason

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords
anxiety, dogs, Souroubea spp, Platanus, Sin Susto™