1. bookVolume 13 (2020): Issue 1 (April 2020)
Journal Details
License
Format
Journal
eISSN
1339-3065
First Published
10 Dec 2012
Publication timeframe
2 times per year
Languages
English
access type Open Access

Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product

Published Online: 29 Jun 2020
Volume & Issue: Volume 13 (2020) - Issue 1 (April 2020)
Page range: 98 - 101
Journal Details
License
Format
Journal
eISSN
1339-3065
First Published
10 Dec 2012
Publication timeframe
2 times per year
Languages
English
Abstract

Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.

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