1. bookVolume 6 (2013): Issue 1 (April 2013)
Journal Details
License
Format
Journal
eISSN
1339-3065
ISSN
1337-978X
First Published
10 Dec 2012
Publication timeframe
2 times per year
Languages
English
access type Open Access

Therapeutic potential of curcumin in medicinal chemistry

Published Online: 22 May 2013
Volume & Issue: Volume 6 (2013) - Issue 1 (April 2013)
Page range: 89 - 99
Journal Details
License
Format
Journal
eISSN
1339-3065
ISSN
1337-978X
First Published
10 Dec 2012
Publication timeframe
2 times per year
Languages
English
Abstract

Extensive research over the past half century has shown that curcumin (diferuloylmethane), a polyphenolic compound of turmeric (Curcuma longa L.), can modulate multiple cell signaling pathways. Extensive clinical trials have addressed the pharmacokinetics, safety, and efficacy of this nutraceutical against numerous diseases in human. Curcumin, known for thousand years as a subject of Ayurvedic medicine, has undergone in recent times remarkable transformation into a drug candidate with prospective multipotent therapeutic application. Characterized by high chemical reactivity, resulting from an extended conjugated double bond system prone to nucleophilic attack, curcumin has been shown to interact with a plethora of molecular targets, in numerous experimental observations. In clinical trials, has been used either alone or in combination with other agent. However, its clinical advance has been limited by its short biological half-life, fast metabolism and poor systemic bioavailability after oral administration. To mitigate the above limitations, recently various formulation of curcumin, including nanoparticles, micelles, liposomes, phytosomes delivery system has been examined. The present review has been devoted towards better understanding of the phytonutraceutic properties of curcumin and turmeric based on their disease specific indications and enhancing their prophylactic and therapeutic nutraceutical qualities. The article deals with the biological activity, mode of action, toxicity and forthcoming application of these leads.

Keywords

Aftab N, Vieira A (2010) Phytother Res 24: 500-502.10.1080/1478641090299079720981613Search in Google Scholar

Aggarwal BB, Harikumar KB (2009) Int J Biochem Cell Biol 41: 40-59.10.1016/j.biocel.2008.06.010263780818662800Search in Google Scholar

Aggarwal BB, Kumar A, Bhortii AC (2003) Anticancer Res 23: 363-398.Search in Google Scholar

Aggarwal BB, Sundaram Ch, Malani N, Tchikawa H (2007) Adv Exp Med Biol 595: 1-75.Search in Google Scholar

Aggarwal BB, Sung B (2008) Trends Pharmacol Sci 30: 85-94.10.1016/j.tips.2008.11.00219110321Search in Google Scholar

Amin T, Bhat SV (2012) Int J Adv Res Technol 1: 1-16.Search in Google Scholar

Anand B, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Mol Pharm 4: 807-818.10.1021/mp700113r17999464Search in Google Scholar

Awasthi R, Kulkarni GT, Pawar VK (2011) Int J Pharm Pharm Sci 3: 1-3.Search in Google Scholar

Balagi S, Chempakam B (2010) Food Chem Toxicol 48: 2951-2959.10.1016/j.fct.2010.07.03220667459Search in Google Scholar

Barzegar A, Moosavi-Movahedi AA (2011) Plos One 6: 1-7.10.1371/journal.pone.0026012318994422016801Search in Google Scholar

Basile V, Ferrari F, Lazzari S, Belluri S, Pigmedoli F, Imbriano C (2009) Biochem Pharmacol 78: 1305-1315.10.1016/j.bcp.2009.06.10519580791Search in Google Scholar

Berginc K, Trontelj J, Basnet NS, Kristl A (2011) Pharmazie 67: 518-524.Search in Google Scholar

Ginpreet K, Meena C (2012) ISRN Pharmacology 1-7.10.5402/2012/104540331695722530133Search in Google Scholar

Goel A, Aggarwal BB (2010) Nutr Cancer 62: 919-930.10.1080/01635581.2010.50983520924967Search in Google Scholar

Goel A, Kunnumakkara AB, Aggarwal BB (2008) Biochem Pharmacol 75: 787-809.10.1016/j.bcp.2007.08.01617900536Search in Google Scholar

Gounder DK, Lingmallu J (2012) Ind Crop Prod 38: 124-131.10.1016/j.indcrop.2012.01.014Search in Google Scholar

Grynkiewicz G, Slifirski P (2012) Acta Biochim Pol 59: 4-11.10.18388/abp.2012_2139Search in Google Scholar

Gupta NK, Dixit VK (2010) J Pharm Sci 100: 1987-1995.10.1002/jps.2239321374628Search in Google Scholar

Gupta SC, Patchva S, Aggarwal BB (2013) AAPS J 15:195-218.10.1208/s12248-012-9432-8353509723143785Search in Google Scholar

Hoom Bong P (2000) Bull Korean Chem Soc 21: 81-86.Search in Google Scholar

Choubey A (2011) IJPSR 2: 807-815.10.1055/s-0030-1258425Search in Google Scholar

Choudhary N, Sekhon BS (2012) J Pharm Educ Res 2: 64-71.Search in Google Scholar

Choudhary N, Sekhon BS (2012) J Pharm Res 3: 64-71.Search in Google Scholar

Jain N, Gupta BP, Thakur N, Jain R, Banweer J, Jain DK, Jain S (2010) Int J Pharm Sci Drug Res 2: 224-228.Search in Google Scholar

Kumar A, Dora J, Singh A (2011) Int J Aplied Biol Pharm Technol 2: 371-379.Search in Google Scholar

Link A, Balaguer F, Goel A (2010) Biochem Pharmacol 80: 1771-1792.10.1016/j.bcp.2010.06.036297401920599773Search in Google Scholar

Maiti K, Mukherjee K, Gautait A, Saha BP, Mukherjee PK (2007) Int J Pharm 330: 155-163.10.1016/j.ijpharm.2006.09.02517112692Search in Google Scholar

Mobasheri A, Henrotin Y, Bieselski HK, Shakibaci M (2012) Int J Mol Sci 13: 4202-4232.10.3390/ijms13044202334421022605974Search in Google Scholar

Mehta A, Kaur G, Chintamaneni M (2012) Intern J Pharmacol 8: 101-107.10.3923/ijp.2012.101.107Search in Google Scholar

Padhye S, Chavan D, Pandey S, Deshpande J, Swamy KV, Sarkar FM (2010) Mini Rev Med Chem 10: 372-387.10.2174/138955710791330891308445120370702Search in Google Scholar

Pathak N, Khandelwal S (2008) Breast Cancer Res Treat 122: 777-785.10.1007/s10549-009-0612-x303912019898931Search in Google Scholar

Prakobwong S, Gupta SC, Kim JH, Sung B, Pinlaor P, Hiraku Y, Aggarwal BB (2011) Carcinogenesis 32: 1372-80.10.1093/carcin/bgr032316512121325634Search in Google Scholar

Reuter S, Gupta SC, Park B, Goel A, Aggarwal BB (2011) Genes Nutr 6: 93-108.10.1007/s12263-011-0222-1309290121516481Search in Google Scholar

Safavy A, Raisch KP, Mantena S, Sanford LL, Sham SW (2007) J Med Chem 50: 6284-6288.10.1021/jm700988f17973470Search in Google Scholar

Shezad A, Wahid F, Lee YS (2010) Arch Pharm 343: 489-499.10.1002/ardp.20090031920726007Search in Google Scholar

Sou K (2012) Recent Patents Nanomedicine 2: 133-163.10.2174/1877912311202020133Search in Google Scholar

Villegas J, Sanchez-Fidalgo S, Alrcon de la Lastra C (2008) Mol Nutr Food Res 52: 1040-1061.10.1002/mnfr.20070028018655004Search in Google Scholar

Yallapu MM, Jaggi M, Chanhan SC (2012) Drug Discovery Today 17: 71-80.10.1016/j.drudis.2011.09.009325919521959306Search in Google Scholar

Zebib B, Mouloungui Z, Noirot V (2010) Bioinorganic Chem Appl 2010: 1-8.10.1155/2010/292760290444620634909Search in Google Scholar

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