1. bookVolume 6 (2013): Issue 1 (April 2013)
Journal Details
License
Format
Journal
eISSN
1339-3065
ISSN
1337-978X
First Published
10 Dec 2012
Publication timeframe
2 times per year
Languages
English
Open Access

Photocytotoxicity of [Cu(N-salicyliden-L-glutamato · 2H2O] · isoquinoline

Published Online: 22 May 2013
Volume & Issue: Volume 6 (2013) - Issue 1 (April 2013)
Page range: 55 - 59
Journal Details
License
Format
Journal
eISSN
1339-3065
ISSN
1337-978X
First Published
10 Dec 2012
Publication timeframe
2 times per year
Languages
English
Abstract

The metal complexes have a significant role in photodynamic therapy (PDT). The most common metals studied for PDT of tumors are transitional metals. In this paper we have studied the copper(II) complexes of N-salicyliden-L-glutamate. The photocytostatic effect was monitored against mouse leukemic cell line L1210. Photocytostatic effect was confirmed for [Cu(N-salicyliden-L-glutamato・2H2O]・isoquinoline (CuCIQ), but it wasn’t observed for the parental molecule [Cu(N-salicyliden-L-glutamato・2H2O]・H2O. CuCIQ had photocytotoxic effect already at 10 μM concentration. Irradiated cells (1050 mJ.cm-2, λ = 365 nm) had half the viability of the cells incubated with CuCIQ in the dark (72 h). Co-incubation of the cells with CuCIQ and ascorbic acid increased this photocytotoxic effect and this effect correlated with the elevated level of lipoperoxidation.

Keywords

Altman SA, Randers L, Rao G (1993) Biotechnol. Prog. 9: 671-674.Search in Google Scholar

de la Haba C, Palacio JR, Martinez P, Morros A (2013) Biochim. Biophys. Acta. 1828: 357-364.Search in Google Scholar

Dolmans D, Fukumura D, Jain RJ (2003) Nat. Rev. Cancer 3: 380-387.Search in Google Scholar

Josefsen LB, Boyle RW (2008) Metal-Based Drugs 2008: 1-24.10.1155/2008/276109253582718815617Search in Google Scholar

Kohutova M, Valent A, Bukovsky MA (2007) Acta Fac. Pharm. Univ. Comenianae 76: 231-235.Search in Google Scholar

O’Connor AE, Gallagher WM, Byrne AT (2009) Photochem. Photobiol. 85: 1053-1074.Search in Google Scholar

Paulikova H, Kadlečikova E, Suchaňova M, Valkova Z, Rauko P, Hudecova D, Valent A (2008) Neoplasma 55: 338-344.Search in Google Scholar

Price KA, Crouch PJ, Volitakis I, Paterson BM, Lim S, Donnelly PS, White AR (2011) Inorg. Chem. 50: 9594-9605.Search in Google Scholar

Sabolova D, Kožurkova M, Plichta T, Ondrušova Z, Hudecova D, Šimkovič M, Paulikova H, Valent A (2011) Int. J. Biol. Macromol. 48: 319-325.Search in Google Scholar

Stalnaya ID, Gharishvili TG (1977) Modern Methods in Biology. Moscow, Medicine: 66-68.Search in Google Scholar

Sturlan S, Baumgartner M, Roth E, Bachleitner-Hofmann T (2003) Blood. 10: 4990-4997.Search in Google Scholar

Vaľkova Z (2004) Diploma thesis, FCHPT STU: 36-40.Search in Google Scholar

Yano S, Hirohara S, Obata M, Hagiya Y, Ogura S, Ikeda A, Kataoka H, Tanaka M, Joh T (2011) J. Photochem. Photobiol. C 12: 46-67.Search in Google Scholar

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