<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>SARS-CoV-2, a newly discovered coronavirus, has been linked to the COVID-19 pandemic and is currently an important public health issue. Despite all the work done to date around the world, there is still no viable treatment for COVID-19. This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B<sub>12</sub>, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective therapeutic approaches available in order to assist researchers and physicians in treating COVID-19 patients.</p>
</abstract>

SARS-CoV-2, a newly discovered coronavirus, has been linked to the COVID-19 pandemic and is currently an important public health issue. Despite all the work done to date around the world, there is still no viable treatment for COVID-19. This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective therapeutic approaches available in order to assist researchers and physicians in treating COVID-19 patients.

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities

South China Hospital, Health Science Center Shenzhen University Guangdong

The Third People’s Hospital of Gansu Province Lanzhou University

The Fourth Affiliated Hospital of China Medical University

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

SARS-CoV-2, a newly discovered coronavirus, has been linked to the COVID-19 pandemic and is currently an important public health issue. Despite all the work...

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities

Published Online: Jun 12, 2023

Page range: 157 - 173

Accepted: Nov 18, 2022

DOI: https://doi.org/10.2478/acph-2023-0014

Keywords
COVID-19, SARS-CoV-2, drugs, natural compounds, vaccine, treatment

© 2023 Sijia Fan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities

Published Online: Jun 12, 2023

Page range: 157 - 173

Accepted: Nov 18, 2022

DOI: https://doi.org/10.2478/acph-2023-0014

KeywordsCOVID-19, SARS-CoV-2, drugs, natural compounds, vaccine, treatment

© 2023 Sijia Fan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
COVID-19, SARS-CoV-2, drugs, natural compounds, vaccine, treatment