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This work aimed to compare the performance of <italic>trans</italic>-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) for transport by Caco-2 cells. The NLC particles (diameter: 102.6 nm) composed of Compritol® 888 ATO, ethyl oleate, Cremophor® EL, and Transcutol® P were larger than the SLNs (diameter: 86.0 nm) formed without liquid lipid (ethyl oleate), and the former had a higher encapsulation efficiency for <italic>trans</italic>-ferulic acid (<italic>p</italic> &lt; 0.05). <italic>In vitro</italic> cultured Caco-2 cell transport was used to simulate intestinal absorption, and the cellular uptake of NLCs was higher than that of SLNs (<italic>p</italic> &lt; 0.05). Compared to SLNs, NLCs greatly enhanced <italic>trans</italic>-ferulic acid permeation through the MillicellTM membrane (<italic>p</italic> &lt; 0.05). This work confirms that NLCs have better properties than SLNs in terms of increasing drug transport by Caco-2 cells. This helps to comprehend the approach by which NLC-mediated oral bioavailability of <italic>trans</italic>-ferulic acid is better than that mediated by SLNs, as shown in our previous report.
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This work aimed to compare the performance of trans-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) for transport by Caco-2 cells. The NLC particles (diameter: 102.6 nm) composed of Compritol® 888 ATO, ethyl oleate, Cremophor® EL, and Transcutol® P were larger than the SLNs (diameter: 86.0 nm) formed without liquid lipid (ethyl oleate), and the former had a higher encapsulation efficiency for trans-ferulic acid (p < 0.05). In vitro cultured Caco-2 cell transport was used to simulate intestinal absorption, and the cellular uptake of NLCs was higher than that of SLNs (p < 0.05). Compared to SLNs, NLCs greatly enhanced trans-ferulic acid permeation through the MillicellTM membrane (p < 0.05). This work confirms that NLCs have better properties than SLNs in terms of increasing drug transport by Caco-2 cells. This helps to comprehend the approach by which NLC-mediated oral bioavailability of trans-ferulic acid is better than that mediated by SLNs, as shown in our previous report.

Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance <italic>trans</italic>-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles

Shanghai University of Traditional Chinese Medicine

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance -ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles

This work aimed to compare the performance of trans-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) for...

Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles

Published Online: Jan 24, 2023

Page range: 133 - 143

Accepted: Aug 08, 2022

DOI: https://doi.org/10.2478/acph-2023-0009

Keywords
solid lipid nanoparticles, nanostructured lipid carriers, intestinal absorption, Caco-2 cell, bioavailability

© 2023 Hongyu Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles

Published Online: Jan 24, 2023

Page range: 133 - 143

Accepted: Aug 08, 2022

DOI: https://doi.org/10.2478/acph-2023-0009

Keywordssolid lipid nanoparticles, nanostructured lipid carriers, intestinal absorption, Caco-2 cell, bioavailability

© 2023 Hongyu Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
solid lipid nanoparticles, nanostructured lipid carriers, intestinal absorption, Caco-2 cell, bioavailability