<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The effects of 3<italic>R</italic>,16<italic>S</italic>-2-hydroxyethyl apovincaminate (HEAPO, RGH-10885) compared with those of two cholinesterase inhibitors, donepezil and galantamine, were examined in naïve Wistar rats using standard active and passive avoidance tests. The active avoidance test (shuttle box) and two passive avoidance tests (step-through and step-down) were performed according to the experimental design. There were 10 groups of rats (<italic>n</italic> = 8) and the substances studied were applied orally before each testing session. In the active avoidance test, the number of conditioned stimuli (avoidances), unconditioned stimuli (escapes) and intertrial crossings were observed. In step-down and step-through passive avoidance tests, the latencies of reactions were observed. All the studied compounds showed positive effects in the learning and memory tests, compared to the controls. It was concluded that HEAPO, donepezil and galantamine had a memory-enhancing effect in active and passive avoidance tests.</p>
</abstract>

The effects of 3R,16S-2-hydroxyethyl apovincaminate (HEAPO, RGH-10885) compared with those of two cholinesterase inhibitors, donepezil and galantamine, were examined in naïve Wistar rats using standard active and passive avoidance tests. The active avoidance test (shuttle box) and two passive avoidance tests (step-through and step-down) were performed according to the experimental design. There were 10 groups of rats (n = 8) and the substances studied were applied orally before each testing session. In the active avoidance test, the number of conditioned stimuli (avoidances), unconditioned stimuli (escapes) and intertrial crossings were observed. In step-down and step-through passive avoidance tests, the latencies of reactions were observed. All the studied compounds showed positive effects in the learning and memory tests, compared to the controls. It was concluded that HEAPO, donepezil and galantamine had a memory-enhancing effect in active and passive avoidance tests.

Effects of 3<italic>R</italic>, 16<italic>S</italic>-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats

Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine

Department of Pharmacology, Toxicology and Pharmacotherapy Faculty of Pharmacy

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Effects of 3, 16-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats

The effects of 3R,16S-2-hydroxyethyl apovincaminate (HEAPO, RGH-10885) compared with those of two cholinesterase inhibitors, donepezil and galantamine, were...

Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats

Published Online: Jan 24, 2023

Page range: 91 - 105

Accepted: Aug 03, 2022

DOI: https://doi.org/10.2478/acph-2023-0006

Keywords
vinpocetine derivatives, 3, 16-2-hydroxyethyl apovincaminate (HEAPO), donepezil, galantamine, memory tests, rats

© 2023 Darinka Dimitrova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats

Published Online: Jan 24, 2023

Page range: 91 - 105

Accepted: Aug 03, 2022

DOI: https://doi.org/10.2478/acph-2023-0006

Keywordsvinpocetine derivatives, 3, 16-2-hydroxyethyl apovincaminate (HEAPO), donepezil, galantamine, memory tests, rats

© 2023 Darinka Dimitrova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
vinpocetine derivatives, 3, 16-2-hydroxyethyl apovincaminate (HEAPO), donepezil, galantamine, memory tests, rats