<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and the rise of resistant parasite types has posed a significant challenge to malaria treatment. To prevent a public health disaster, novel antimalarial agents with single-dosage therapies, extensive curative capability, and new mechanisms are urgently needed. There are several approaches to developing antimalarial drugs, ranging from alterations of current drugs to the creation of new compounds with specific targeting abilities. The availability of multiple genomic techniques, as well as recent advancements in parasite biology, provides a varied collection of possible targets for the development of novel treatments. A number of promising pharmacological interference targets have been uncovered in modern times. As a result, our review concentrates on the most current scientific and technical progress in the innovation of new antimalarial medications. The protein kinases, choline transport inhibitors, dihydroorotate dehydrogenase inhibitors, isoprenoid biosynthesis inhibitors, and enzymes involved in the metabolism of lipids and replication of deoxyribonucleic acid, are among the most fascinating antimalarial target proteins presently being investigated. The new cellular targets and drugs which can inhibit malaria and their development techniques are summarised in this study.</p>
</abstract>

Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and the rise of resistant parasite types has posed a significant challenge to malaria treatment. To prevent a public health disaster, novel antimalarial agents with single-dosage therapies, extensive curative capability, and new mechanisms are urgently needed. There are several approaches to developing antimalarial drugs, ranging from alterations of current drugs to the creation of new compounds with specific targeting abilities. The availability of multiple genomic techniques, as well as recent advancements in parasite biology, provides a varied collection of possible targets for the development of novel treatments. A number of promising pharmacological interference targets have been uncovered in modern times. As a result, our review concentrates on the most current scientific and technical progress in the innovation of new antimalarial medications. The protein kinases, choline transport inhibitors, dihydroorotate dehydrogenase inhibitors, isoprenoid biosynthesis inhibitors, and enzymes involved in the metabolism of lipids and replication of deoxyribonucleic acid, are among the most fascinating antimalarial target proteins presently being investigated. The new cellular targets and drugs which can inhibit malaria and their development techniques are summarised in this study.

Recent approaches in the drug research and development of novel antimalarial drugs with new targets

Department of Biomedical Sciences, College of Clinical Pharmacy

Department of Biotechnology and Food Science Faculty of Applied Sciences

College of Clinical Pharmacy, King Faisal University

Department of Pharmaceutical Sciences, Faculty of Pharmacy

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and...

Recent approaches in the drug research and development of novel antimalarial drugs with new targets

Published Online: Jan 24, 2023

Page range: 1 - 27

Accepted: Sep 16, 2022

DOI: https://doi.org/10.2478/acph-2023-0001

Keywords
antimalarial drugs, protein kinases, dihydroorotate dehydrogenase

© 2023 Naveen Kumar Reddy Chinnappanna et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Recent approaches in the drug research and development of novel antimalarial drugs with new targets

Published Online: Jan 24, 2023

Page range: 1 - 27

Accepted: Sep 16, 2022

DOI: https://doi.org/10.2478/acph-2023-0001

Keywordsantimalarial drugs, protein kinases, dihydroorotate dehydrogenase

© 2023 Naveen Kumar Reddy Chinnappanna et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
antimalarial drugs, protein kinases, dihydroorotate dehydrogenase