<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Allergic asthma is an inflammatory disease of the airways which has a complex etiology. Punicalagin, a major polyphenol present in pomegranates, is reported to possess various biological properties including antioxidant and antiproliferative effects. The current research aimed to evaluate the antiasthmatic effects of punicalagin in an ovalbumin (OVA)-induced experimental model of asthma in female BALB/c mice. Treatment group animals received punicalagin (12.5, 25 or 50 mg kg<sup>−1</sup> body mass) per day for 21 days from day 1 of OVA injection. Dexamethasone (DEX) was administered to a separate group of mice, as the standard drug control. Inflammatory cell infiltration into the broncho-alveolar lavage fluid (BALF) was substantially decreased in punicalagin-treated mice. Punicalagin reduced Th2-derived cytokines and OVA-specific IgE levels. The IL-4/STAT6 and Notch/GATA3 signalling pathways were regulated on punicalagin administration. The data obtained illustrate the potency of punicalagin as an anti-asthmatic drug. Conclusively, the study’s observations suggest the potential therapeutic efficiency of punicalagin in allergic asthma.</p>
</abstract>

Allergic asthma is an inflammatory disease of the airways which has a complex etiology. Punicalagin, a major polyphenol present in pomegranates, is reported to possess various biological properties including antioxidant and antiproliferative effects. The current research aimed to evaluate the antiasthmatic effects of punicalagin in an ovalbumin (OVA)-induced experimental model of asthma in female BALB/c mice. Treatment group animals received punicalagin (12.5, 25 or 50 mg kg−1 body mass) per day for 21 days from day 1 of OVA injection. Dexamethasone (DEX) was administered to a separate group of mice, as the standard drug control. Inflammatory cell infiltration into the broncho-alveolar lavage fluid (BALF) was substantially decreased in punicalagin-treated mice. Punicalagin reduced Th2-derived cytokines and OVA-specific IgE levels. The IL-4/STAT6 and Notch/GATA3 signalling pathways were regulated on punicalagin administration. The data obtained illustrate the potency of punicalagin as an anti-asthmatic drug. Conclusively, the study’s observations suggest the potential therapeutic efficiency of punicalagin in allergic asthma.

Punicalagin attenuated allergic airway inflammation <italic>via</italic> regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways

Department of the division of general medicine, The People’s Hospital of Guangxi Zhuang Autonomous Region Nanning 530021

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Punicalagin attenuated allergic airway inflammation  regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways

Allergic asthma is an inflammatory disease of the airways which has a complex etiology. Punicalagin, a major polyphenol present in pomegranates, is reported to...

Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways

Published Online: Oct 18, 2022

Page range: 561 - 573

Accepted: May 11, 2022

DOI: https://doi.org/10.2478/acph-2022-0038

Keywords
asthma, GATA3, inflammation, interleukins, Notch signal, punicalagin

© 2022 Li Yu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways

Published Online: Oct 18, 2022

Page range: 561 - 573

Accepted: May 11, 2022

DOI: https://doi.org/10.2478/acph-2022-0038

Keywordsasthma, GATA3, inflammation, interleukins, Notch signal, punicalagin

© 2022 Li Yu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
asthma, GATA3, inflammation, interleukins, Notch signal, punicalagin