<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Nebulization is a very effective method of drug administration. This technique has been popular since ancient times when inhalation of plants rich in tropane alkaloids with spasmolytic and analgesic effects was widely used. Undoubtedly, the invention of anasthesia in the 19th century had an influence on the development of this technique. It resulted in the search for devices that facilitated anasthesia such as pulveriser or hydronium. From the second half of the 21st century, when the first DPI and MDI inhalers were launched, the constant development of aerosol therapy has been noticed. This is due to the fact that nebulization, compared with other means of medicinal substance application (such as oral and intravenous routes of administration), is safer and it exhibits a positive dose/efficacy ratio connected to the reduction of the dose. It enables drugs administration through the lung and possesses very fast onset action. Therefore, various drugs prescribed in respiratory diseases (such as corticosteroids, β-agonists, anticholinergics) are present on the market in a form of an aerosol.</p>
</abstract>

Nebulization is a very effective method of drug administration. This technique has been popular since ancient times when inhalation of plants rich in tropane alkaloids with spasmolytic and analgesic effects was widely used. Undoubtedly, the invention of anasthesia in the 19th century had an influence on the development of this technique. It resulted in the search for devices that facilitated anasthesia such as pulveriser or hydronium. From the second half of the 21st century, when the first DPI and MDI inhalers were launched, the constant development of aerosol therapy has been noticed. This is due to the fact that nebulization, compared with other means of medicinal substance application (such as oral and intravenous routes of administration), is safer and it exhibits a positive dose/efficacy ratio connected to the reduction of the dose. It enables drugs administration through the lung and possesses very fast onset action. Therefore, various drugs prescribed in respiratory diseases (such as corticosteroids, β-agonists, anticholinergics) are present on the market in a form of an aerosol.

The history, current state and perspectives of aerosol therapy

Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy

Department of Pharmaceutical Botany Faculty of Pharmacy

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The history, current state and perspectives of aerosol therapy"}

Nebulization is a very effective method of drug administration. This technique has been popular since ancient times when inhalation of plants rich in tropane...

The history, current state and perspectives of aerosol therapy

Article Category: Review

Published Online: Dec 30, 2021

Page range: 225 - 243

Accepted: Jun 09, 2021

DOI: https://doi.org/10.2478/acph-2022-0017

Keywords
inhalation, nebulization, plant raw materials, metered-dose inhalers and dry-powder inhalers

© 2022 Bartłomiej Rospond., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The history, current state and perspectives of aerosol therapy

Article Category: Review

Published Online: Dec 30, 2021

Page range: 225 - 243

Accepted: Jun 09, 2021

DOI: https://doi.org/10.2478/acph-2022-0017

Keywordsinhalation, nebulization, plant raw materials, metered-dose inhalers and dry-powder inhalers

© 2022 Bartłomiej Rospond., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
inhalation, nebulization, plant raw materials, metered-dose inhalers and dry-powder inhalers