<abstract xmlns="http://www.w3.org/1999/xhtml">The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry and blood chemistry. An acute dose of mazindol and metformin administered <italic>per os</italic>, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (<italic>ED</italic>40t) did not differ from the experimental effective dose 40 (<italic>ED</italic>40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student′s <italic>t</italic>-test. In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of <italic>ED</italic>40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. Results suggest that mazindol-metformin combination exerts an additive anorectic effect, as well as anxiolytic and hypoglycemic properties. Mazindol-metformin combination might be useful in obese patients with anxiety disorders or diabetes risk factors.</abstract>

The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry and blood chemistry. An acute dose of mazindol and metformin administered per os, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (ED40t) did not differ from the experimental effective dose 40 (ED40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student′s t-test. In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of ED40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. Results suggest that mazindol-metformin combination exerts an additive anorectic effect, as well as anxiolytic and hypoglycemic properties. Mazindol-metformin combination might be useful in obese patients with anxiety disorders or diabetes risk factors.

Efficacy and safety of the metformin-mazindol anorectic combination in rat

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Efficacy and safety of the metformin-mazindol anorectic combination in rat"}

The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used...

Efficacy and safety of the metformin-mazindol anorectic combination in rat

Published Online: Nov 04, 2020

Page range: 279 - 291

Accepted: Jun 20, 2020

DOI: https://doi.org/10.2478/acph-2021-0019

Keywords
mazindol-metformin combination, anorectic interaction, anxiolysis, hypoglycemic effect

© 2021 Federico Argüelles-Tello et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Efficacy and safety of the metformin-mazindol anorectic combination in rat

Published Online: Nov 04, 2020

Page range: 279 - 291

Accepted: Jun 20, 2020

DOI: https://doi.org/10.2478/acph-2021-0019

Keywordsmazindol-metformin combination, anorectic interaction, anxiolysis, hypoglycemic effect

© 2021 Federico Argüelles-Tello et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
mazindol-metformin combination, anorectic interaction, anxiolysis, hypoglycemic effect