<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of <italic>in vitro</italic> active pharmaceutical ingredient release. The aim here was to develop an alternative method to the commonly used United States Pharmacopoeia (USP) 2 method, based on the flow-through cell. This system extends the release time and enables more detailed sample discrimination according to formulation. It could be used as a tool for <italic>in vivo</italic> prediction of drug release rates from buccal film formulations. The flow cell contains two chambers separated by a membrane through which the released active pharmaceutical ingredient is measured. Vital system variables and their effects on the release rate of the model active pharmaceutical ingredient are presented for formulations based on sodium alginate polymer. The method reflects the differences between films and is shown to be discriminatory for evaluation of buccal formulations.</p></abstract>

Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method to the commonly used United States Pharmacopoeia (USP) 2 method, based on the flow-through cell. This system extends the release time and enables more detailed sample discrimination according to formulation. It could be used as a tool for in vivo prediction of drug release rates from buccal film formulations. The flow cell contains two chambers separated by a membrane through which the released active pharmaceutical ingredient is measured. Vital system variables and their effects on the release rate of the model active pharmaceutical ingredient are presented for formulations based on sodium alginate polymer. The method reflects the differences between films and is shown to be discriminatory for evaluation of buccal formulations.

Advanced flow cell design for <italic>in vitro</italic> release testing of mucoadhesive buccal films

Faculty of Pharmacy, Chair of Pharmaceutical Technology

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Advanced flow cell design for  release testing of mucoadhesive buccal films

Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in...

Advanced flow cell design for in vitro release testing of mucoadhesive buccal films

Published Online: Feb 17, 2020

Page range: 359 - 371

Accepted: Oct 25, 2019

DOI: https://doi.org/10.2478/acph-2020-0030

Keywords
release rate, buccal films, hydrostatic pressure, flow cell

© 2020 Blaž Grilc et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Advanced flow cell design for in vitro release testing of mucoadhesive buccal films

Published Online: Feb 17, 2020

Page range: 359 - 371

Accepted: Oct 25, 2019

DOI: https://doi.org/10.2478/acph-2020-0030

Keywordsrelease rate, buccal films, hydrostatic pressure, flow cell

© 2020 Blaž Grilc et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
release rate, buccal films, hydrostatic pressure, flow cell