<abstract xmlns="http://www.w3.org/1999/xhtml">Heliangolide is a naturally occurring sesquiterpene lactone and its derivatives are biologically active compounds present in most medicinal plants. This study evaluated the antioxidant and antidiabetic properties of a heliangolide sesquiterpene lactone isolated from <italic>Helianthus annuus</italic> L. leaves. The heliangolide sesquiterpene lactone was isolated through a combination of solvent-solvent partitioning, column chromatography, thin layer chromatography and high-performance liquid chromatography techniques. The antioxidant activity of the compound was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide radical scavenging assays while the antidiabetic effects were investigated in alloxan-induced diabetic rats. The heliangolide derivative at the concentration of 954.2 µmol L−1 showed 23.7 % DPPH and 26 % nitric oxide radical inhibitions compared with 96.6 and 50.9 %, resp., displayed by the controls (2,271.2 µmol L−1). It also reduced the fasting blood glucose (FBG) levels in a time-dependent manner. The highest activity was recorded within 6 h post-treatment at 0.2 mmol kg−1 bm. The heliangolide derivative exhibited significant (<italic>p</italic> &lt; 0.05) antioxidant and antidiabetic properties and provides a basis for further development of constituents of <italic>Helianthus annuus</italic> leaves for the management of such diseases.</abstract>

Heliangolide is a naturally occurring sesquiterpene lactone and its derivatives are biologically active compounds present in most medicinal plants. This study evaluated the antioxidant and antidiabetic properties of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves. The heliangolide sesquiterpene lactone was isolated through a combination of solvent-solvent partitioning, column chromatography, thin layer chromatography and high-performance liquid chromatography techniques. The antioxidant activity of the compound was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide radical scavenging assays while the antidiabetic effects were investigated in alloxan-induced diabetic rats. The heliangolide derivative at the concentration of 954.2 µmol L−1 showed 23.7 % DPPH and 26 % nitric oxide radical inhibitions compared with 96.6 and 50.9 %, resp., displayed by the controls (2,271.2 µmol L−1). It also reduced the fasting blood glucose (FBG) levels in a time-dependent manner. The highest activity was recorded within 6 h post-treatment at 0.2 mmol kg−1 bm. The heliangolide derivative exhibited significant (p < 0.05) antioxidant and antidiabetic properties and provides a basis for further development of constituents of Helianthus annuus leaves for the management of such diseases.

Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from <italic>Helianthus annuus</italic> L. leaves

Department of Veterinary Physiology and Pharmacology

Department of Pharmaceutical and Medicinal Chemistry

Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from  L. leaves

Heliangolide is a naturally occurring sesquiterpene lactone and its derivatives are biologically active compounds present in most medicinal plants. This study...

Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves

Published Online: Jan 16, 2020

Page range: 215 - 226

Accepted: Jun 09, 2019

DOI: https://doi.org/10.2478/acph-2020-0019

Keywords
heliangolide derivative, antidiabetic, antioxidant

© 2020 Samuel O. Onoja et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves

Published Online: Jan 16, 2020

Page range: 215 - 226

Accepted: Jun 09, 2019

DOI: https://doi.org/10.2478/acph-2020-0019

Keywordsheliangolide derivative, antidiabetic, antioxidant

© 2020 Samuel O. Onoja et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
heliangolide derivative, antidiabetic, antioxidant