<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Despite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect, poly(lactic<italic>-co-</italic>glycolic acid derivatives are widely used in drug delivery. Most frequent attempts to improve their properties are blending with other polymers or synthesis of block copolymers. We introduce a new class of branched poly(lactic<italic>-co-</italic>glycolic acid) derivatives as promising biodegradable carriers for prolonged or targeted drug release systems, employed as thin adhesive films, solid dispersions, <italic>in situ</italic> forming implants or nanoparticles. A series of poly(lactic<italic>-co-</italic>glycolic acid) derivatives with lower molar mass and star or comb architecture were synthesized by a simple, catalyst free, direct melt polycondensation method not requiring purification of the obtained sterile product by precipitation. Branching monomers used were mannitol, pentaerythritol, dipentaerythritol, tripentaerythritol and polyacrylic acid. The products were characterized by molar mass averages, average branching ratio, rheological and thermal properties.</p>
</abstract>

Despite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect, poly(lactic-co-glycolic acid derivatives are widely used in drug delivery. Most frequent attempts to improve their properties are blending with other polymers or synthesis of block copolymers. We introduce a new class of branched poly(lactic-co-glycolic acid) derivatives as promising biodegradable carriers for prolonged or targeted drug release systems, employed as thin adhesive films, solid dispersions, in situ forming implants or nanoparticles. A series of poly(lactic-co-glycolic acid) derivatives with lower molar mass and star or comb architecture were synthesized by a simple, catalyst free, direct melt polycondensation method not requiring purification of the obtained sterile product by precipitation. Branching monomers used were mannitol, pentaerythritol, dipentaerythritol, tripentaerythritol and polyacrylic acid. The products were characterized by molar mass averages, average branching ratio, rheological and thermal properties.

Branched PLGA derivatives with tailored drug delivery properties

Institute of Chemistry and Technology of Macromolecular Materials

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Branched PLGA derivatives with tailored drug delivery properties"}

Despite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect,...

Branched PLGA derivatives with tailored drug delivery properties

Published Online: Nov 01, 2019

Page range: 63 - 75

Accepted: Feb 26, 2019

DOI: https://doi.org/10.2478/acph-2020-0011

Keywords
PLGA, branching, star polymer, polymer synthesis, light scattering

© 2020 Eva Snejdrova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Branched PLGA derivatives with tailored drug delivery properties

Published Online: Nov 01, 2019

Page range: 63 - 75

Accepted: Feb 26, 2019

DOI: https://doi.org/10.2478/acph-2020-0011

KeywordsPLGA, branching, star polymer, polymer synthesis, light scattering

© 2020 Eva Snejdrova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
PLGA, branching, star polymer, polymer synthesis, light scattering