<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, many researchers examined the different physico-chemical modifications of poly(3-hydroxybutyrate) in order to improve its properties for use in the field of bone tissue engineering. Poly(3-hydroxybutyrate) composites with hydroxyapatite and bioglass are intensively tested with animal and human osteoblasts <italic>in vitro</italic> to provide information about their biocompatibility, biodegradability and osteoinductivity. Good bone regeneration was proven when poly(3-hydroxy-butyrate) patches were implanted <italic>in vivo</italic> in bone tissue of cats, minipigs and rats. This review summarizes the recent reports of <italic>in vitro</italic> and <italic>in vivo</italic> studies of pure poly(3-hydroxy-butyrate) and poly(3-hydroxybutyrate) composites with the emphasis on their bioactivity and biocompatibility with bone cells.</p>
</abstract>

Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, many researchers examined the different physico-chemical modifications of poly(3-hydroxybutyrate) in order to improve its properties for use in the field of bone tissue engineering. Poly(3-hydroxybutyrate) composites with hydroxyapatite and bioglass are intensively tested with animal and human osteoblasts in vitro to provide information about their biocompatibility, biodegradability and osteoinductivity. Good bone regeneration was proven when poly(3-hydroxy-butyrate) patches were implanted in vivo in bone tissue of cats, minipigs and rats. This review summarizes the recent reports of in vitro and in vivo studies of pure poly(3-hydroxy-butyrate) and poly(3-hydroxybutyrate) composites with the emphasis on their bioactivity and biocompatibility with bone cells.

Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering

Faculty of Medicine, Institute of Biomedical Sciences

Faculty of Chemistry and Chemical Engineering

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering"}

Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches,...

Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering

Published Online: Nov 01, 2019

Page range: 1 - 15

Accepted: Feb 26, 2019

DOI: https://doi.org/10.2478/acph-2020-0007

Keywords
poly(3-hydroxybutyrate), biopolymers, bone tissue engineering, osteoblasts

© 2020 Barbara Dariš et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering

Published Online: Nov 01, 2019

Page range: 1 - 15

Accepted: Feb 26, 2019

DOI: https://doi.org/10.2478/acph-2020-0007

Keywordspoly(3-hydroxybutyrate), biopolymers, bone tissue engineering, osteoblasts

© 2020 Barbara Dariš et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
poly(3-hydroxybutyrate), biopolymers, bone tissue engineering, osteoblasts