<abstract xmlns="http://www.w3.org/1999/xhtml">The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats. We used a non-invasive “tail-cuff” method to measure the arterial blood pressure. Female and male Wistar rats were treated separately with high and low dosages of frovatriptan and almotriptan. Male and female rats showed reduction in all hemodynamic parameters, but only male rats showed an increase in the heart rate. In general, we could say that both almotriptan and frovatriptan potentiate cardiovascular safety.</abstract>

The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats. We used a non-invasive “tail-cuff” method to measure the arterial blood pressure. Female and male Wistar rats were treated separately with high and low dosages of frovatriptan and almotriptan. Male and female rats showed reduction in all hemodynamic parameters, but only male rats showed an increase in the heart rate. In general, we could say that both almotriptan and frovatriptan potentiate cardiovascular safety.

Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats

Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy

Department of Physiology, Faculty of Medicine

Technological Center of Emergency Medicine (TCEMED)

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan...

Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats

Published Online: Jan 16, 2020

Page range: 239 - 247

Accepted: May 13, 2019

DOI: https://doi.org/10.2478/acph-2020-0005

Keywords
almotriptan, frovatriptan, rat, arterial pressure

© 2020 Kremena Saracheva et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats

Published Online: Jan 16, 2020

Page range: 239 - 247

Accepted: May 13, 2019

DOI: https://doi.org/10.2478/acph-2020-0005

Keywordsalmotriptan, frovatriptan, rat, arterial pressure

© 2020 Kremena Saracheva et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
almotriptan, frovatriptan, rat, arterial pressure