<abstract xmlns="http://www.w3.org/1999/xhtml"><p><italic>Lamium album</italic> and <italic>Lamium purpureum</italic> are species belonging to the genus <italic>Lamium</italic>. Aerial parts of the two species and roots of <italic>Lamium album</italic> have applications in human and veterinary traditional medicine. Haemostatic properties of butanolic extracts of <italic>Lamium</italic> species were investigated by two experimental models in Wistar rats: haemostatic test by tail bleeding time determination and acenocoumarolcarrageenan test. Results of the haemostatic test by tail bleeding determination demonstrated haemostatic activity of both extracts. In the acenocoumarol-carrageenan test, only the <italic>Lamium album</italic> extract showed haemostatic activity, comparable to that of vitamin K. Based on the qualitative chemical data on iridoid glycosides (HPTLC), 8-acetylshanzhiside methyl ester might be assumed to be responsible for haemostatic activity. Based on the acute toxicity test, none of the extracts showed toxicity.</p></abstract>

Lamium album and Lamium purpureum are species belonging to the genus Lamium. Aerial parts of the two species and roots of Lamium album have applications in human and veterinary traditional medicine. Haemostatic properties of butanolic extracts of Lamium species were investigated by two experimental models in Wistar rats: haemostatic test by tail bleeding time determination and acenocoumarolcarrageenan test. Results of the haemostatic test by tail bleeding determination demonstrated haemostatic activity of both extracts. In the acenocoumarol-carrageenan test, only the Lamium album extract showed haemostatic activity, comparable to that of vitamin K. Based on the qualitative chemical data on iridoid glycosides (HPTLC), 8-acetylshanzhiside methyl ester might be assumed to be responsible for haemostatic activity. Based on the acute toxicity test, none of the extracts showed toxicity.

Haemostatic activity of butanolic extracts of <italic>Lamium album</italic> and <italic>Lamium purpureum</italic> aerial parts

Department of Pharmaceutical Biotechnology

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Haemostatic activity of butanolic extracts of  and  aerial parts

Lamium album and Lamium purpureum are species belonging to the genus Lamium. Aerial parts of the two species and roots of Lamium album have applications in...

Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts

Published Online: Jun 26, 2019

Page range: 443 - 449

Accepted: Dec 28, 2018

DOI: https://doi.org/10.2478/acph-2019-0026

Keywords
aerial parts, butanolic extract, haemostatic activity, toxicity

© 2019 Corina Bubueanu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts

Published Online: Jun 26, 2019

Page range: 443 - 449

Accepted: Dec 28, 2018

DOI: https://doi.org/10.2478/acph-2019-0026

Keywordsaerial parts, butanolic extract, haemostatic activity, toxicity

© 2019 Corina Bubueanu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
aerial parts, butanolic extract, haemostatic activity, toxicity