<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis <italic>via</italic> suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formation ability and suppressed cell migration. TAD1822-7 effectively inhibited blood vessel formation in an aortic ring assay to examine angiogenesis. Moreover, it also down regulated the expression of VEGFR2, VEGFR3, CD34, PLCγ, Akt, MMP2, MMP9, and CXCR4, and suppressed the expression of EphrinB2 and its PDZ protein, PICK1, in Bel-7402 cells. These results indicate that TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells <italic>via</italic> suppression of EphrinB2 and the related signaling pathways.</p></abstract>

The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formation ability and suppressed cell migration. TAD1822-7 effectively inhibited blood vessel formation in an aortic ring assay to examine angiogenesis. Moreover, it also down regulated the expression of VEGFR2, VEGFR3, CD34, PLCγ, Akt, MMP2, MMP9, and CXCR4, and suppressed the expression of EphrinB2 and its PDZ protein, PICK1, in Bel-7402 cells. These results indicate that TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells via suppression of EphrinB2 and the related signaling pathways.

Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis <italic>via</italic> suppression of EphrinB2 and related signaling pathways

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis  suppression of EphrinB2 and related signaling pathways

The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell...

Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways

Published Online: Jun 26, 2019

Page range: 423 - 431

Accepted: Dec 03, 2018

DOI: https://doi.org/10.2478/acph-2019-0021

Keywords
TAD1822-7, EphrinB2, Bel-7402 cells, proliferation, migration, anti-angiogenesis

© 2019 Rui Liu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways

Published Online: Jun 26, 2019

Page range: 423 - 431

Accepted: Dec 03, 2018

DOI: https://doi.org/10.2478/acph-2019-0021

KeywordsTAD1822-7, EphrinB2, Bel-7402 cells, proliferation, migration, anti-angiogenesis

© 2019 Rui Liu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
TAD1822-7, EphrinB2, Bel-7402 cells, proliferation, migration, anti-angiogenesis