<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the relatively novel and promising approaches is the manufacture of orodispersible films (ODFs), which is an upcoming area of interest in drug delivery. They are defined as polymer thin films that disintegrate in the oral cavity within seconds, without drinking water or chewing, and eliminate the risk of choking. Gaining special usefulness in therapies of children and the elderly, ODFs seem to fill the gap in the range of preparations available for these groups of patients. As no detailed monography of ODFs including testing methods and uniform requirements has been presented in any of the pharmacopoeias to date, the aim of this article is to give an overview of the applied testing methods, their modifications and innovative approaches related to ODF quality assessment.</p></abstract>

In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the relatively novel and promising approaches is the manufacture of orodispersible films (ODFs), which is an upcoming area of interest in drug delivery. They are defined as polymer thin films that disintegrate in the oral cavity within seconds, without drinking water or chewing, and eliminate the risk of choking. Gaining special usefulness in therapies of children and the elderly, ODFs seem to fill the gap in the range of preparations available for these groups of patients. As no detailed monography of ODFs including testing methods and uniform requirements has been presented in any of the pharmacopoeias to date, the aim of this article is to give an overview of the applied testing methods, their modifications and innovative approaches related to ODF quality assessment.

How to assess orodispersible film quality? A review of applied methods and their modifications

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer...

How to assess orodispersible film quality? A review of applied methods and their modifications

Published Online: Mar 28, 2019

Page range: 155 - 176

Accepted: Nov 16, 2018

DOI: https://doi.org/10.2478/acph-2019-0018

Keywords
orodispersible film, quality assessment, ODF testing methods, mechanical properties, disintegration time

© 2019 Katarzyna Wasilewska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

How to assess orodispersible film quality? A review of applied methods and their modifications

Published Online: Mar 28, 2019

Page range: 155 - 176

Accepted: Nov 16, 2018

DOI: https://doi.org/10.2478/acph-2019-0018

Keywordsorodispersible film, quality assessment, ODF testing methods, mechanical properties, disintegration time

© 2019 Katarzyna Wasilewska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
orodispersible film, quality assessment, ODF testing methods, mechanical properties, disintegration time