<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Use of transdermal patches can evade many issues associated with oral drug delivery, such as first-pass hepatic metabolism, enzymatic digestion attack, drug hydrolysis and degradation in acidic media, drug fluctuations, and gastrointestinal irritation. This article reviews various transdermal patches available in the market, types, structural components, polymer role, and the required assessment tools. Although transdermal patches have medical applications for smoking cessation, pain relief, osteoporosis, contraception, motion sickness, angina pectoris, and cardiac disorders, advances in formulation development are ongoing to make transdermal patches capable of delivering more challenging drugs. Transdermal patches can be tailored and developed according to the physicochemical properties of active and inactive components, and applicability for long-term use. Therefore, a number of chemical approaches and physical techniques for transdermal patch development are under investigation.</p></abstract>

Use of transdermal patches can evade many issues associated with oral drug delivery, such as first-pass hepatic metabolism, enzymatic digestion attack, drug hydrolysis and degradation in acidic media, drug fluctuations, and gastrointestinal irritation. This article reviews various transdermal patches available in the market, types, structural components, polymer role, and the required assessment tools. Although transdermal patches have medical applications for smoking cessation, pain relief, osteoporosis, contraception, motion sickness, angina pectoris, and cardiac disorders, advances in formulation development are ongoing to make transdermal patches capable of delivering more challenging drugs. Transdermal patches can be tailored and developed according to the physicochemical properties of active and inactive components, and applicability for long-term use. Therefore, a number of chemical approaches and physical techniques for transdermal patch development are under investigation.

Transdermal patches: Design and current approaches to painless drug delivery

, Zawata Road, Nablus-West Bank, Palestinian Authority

Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine

Al Ain University of Science and Technology

Faculty of Pharmacy and Pharmaceutical Sciences

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Transdermal patches: Design and current approaches to painless drug delivery"}

Use of transdermal patches can evade many issues associated with oral drug delivery, such as first-pass hepatic metabolism, enzymatic digestion attack, drug...

Transdermal patches: Design and current approaches to painless drug delivery

Published Online: Mar 28, 2019

Page range: 197 - 215

Accepted: Nov 07, 2018

DOI: https://doi.org/10.2478/acph-2019-0016

Keywords
transdermal patch, transdermal drug delivery, polymer matrix, adhesives, skin formulation

© 2019 Othman A. Al Hanbali et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Transdermal patches: Design and current approaches to painless drug delivery

Published Online: Mar 28, 2019

Page range: 197 - 215

Accepted: Nov 07, 2018

DOI: https://doi.org/10.2478/acph-2019-0016

Keywordstransdermal patch, transdermal drug delivery, polymer matrix, adhesives, skin formulation

© 2019 Othman A. Al Hanbali et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
transdermal patch, transdermal drug delivery, polymer matrix, adhesives, skin formulation