<abstract xmlns="http://www.w3.org/1999/xhtml">A simple and sensitive spectrofluorimetric method for determination of atenolol (ATE) using gold nanoparticles (AuNPs) was developed. The method is based on the quenching effect of atenolol on photoluminescence of AuNPs at <italic>λ</italic>em = 705 nm. Variables affecting luminescence of gold nanoparticles such as the solvent, pH value and surfactant were studied and optimized. The method was preliminarily validated according to ICH guidelines. A linear correlation was recorded within the range of 1.0–10 mg mL−1 ATE with the coefficient of determination <italic>R</italic>2 of 0.999. The limit of detection and limit of quantitation for atenolol were found to be 0.87 and 2.64 mg mL−1, resp. Good recoveries in the range of 98.7–100.0 % were obtained for spiked samples. The proposed method was applied successfully to assaying atenolol in pharmaceuticals formulations.</abstract>

A simple and sensitive spectrofluorimetric method for determination of atenolol (ATE) using gold nanoparticles (AuNPs) was developed. The method is based on the quenching effect of atenolol on photoluminescence of AuNPs at λem = 705 nm. Variables affecting luminescence of gold nanoparticles such as the solvent, pH value and surfactant were studied and optimized. The method was preliminarily validated according to ICH guidelines. A linear correlation was recorded within the range of 1.0–10 mg mL−1 ATE with the coefficient of determination R2 of 0.999. The limit of detection and limit of quantitation for atenolol were found to be 0.87 and 2.64 mg mL−1, resp. Good recoveries in the range of 98.7–100.0 % were obtained for spiked samples. The proposed method was applied successfully to assaying atenolol in pharmaceuticals formulations.

Spectrofluorimetric method for atenolol determination based on gold nanoparticles

Department of Chemistry, College of Science

Department of Chemistry, Faculty of Science

Textile Research Division, National Research Center

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A simple and sensitive spectrofluorimetric method for determination of atenolol (ATE) using gold nanoparticles (AuNPs) was developed. The method is based on...

Spectrofluorimetric method for atenolol determination based on gold nanoparticles

Published Online: Apr 26, 2018

Page range: 243 - 250

Accepted: Jan 21, 2018

DOI: https://doi.org/10.2478/acph-2018-0020

Keywords
atenolol, spectrofluorimetry, gold nanoparticles

© 2018 Esam Bakir et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Spectrofluorimetric method for atenolol determination based on gold nanoparticles

Published Online: Apr 26, 2018

Page range: 243 - 250

Accepted: Jan 21, 2018

DOI: https://doi.org/10.2478/acph-2018-0020

Keywordsatenolol, spectrofluorimetry, gold nanoparticles

© 2018 Esam Bakir et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
atenolol, spectrofluorimetry, gold nanoparticles