<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with HBV-related liver failure treated with nucleoside analogues were used to conduct a network meta-analysis. A total of 1660 patients from 12 articles about the efficacy of lamivudine, entecavir, telbivudine and tenofovir for HBV-related liver failure treatment were recruited in the study. The highest two- and three-month survival rate was recorded for patients using tenofovir. The end-stage liver disease (MELD) score and mortality in patients undergoing tenofovir treatment were the lowest. Patients treated with telbivudine had the highest one-month survival rate. Patients receiving enticavir therapy showed the lowest HBV DNA level. Our results indicate that tenofovir may be the best therapy for the treatment of HBV-related liver failure compared to other nucleoside analogues (including lamivudine, entecavir and telbivudine) and non-NAs treatment.</p></abstract>

The purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with HBV-related liver failure treated with nucleoside analogues were used to conduct a network meta-analysis. A total of 1660 patients from 12 articles about the efficacy of lamivudine, entecavir, telbivudine and tenofovir for HBV-related liver failure treatment were recruited in the study. The highest two- and three-month survival rate was recorded for patients using tenofovir. The end-stage liver disease (MELD) score and mortality in patients undergoing tenofovir treatment were the lowest. Patients treated with telbivudine had the highest one-month survival rate. Patients receiving enticavir therapy showed the lowest HBV DNA level. Our results indicate that tenofovir may be the best therapy for the treatment of HBV-related liver failure compared to other nucleoside analogues (including lamivudine, entecavir and telbivudine) and non-NAs treatment.

Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with...

Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis

Published Online: Feb 16, 2018

Page range: 19 - 30

Accepted: Dec 04, 2017

DOI: https://doi.org/10.2478/acph-2018-0010

Keywords
liver failure, hepatitis B virus, nucleoside analogue, tenofovir, network meta-analysis

© by Xinmin Zhou

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis

Published Online: Feb 16, 2018

Page range: 19 - 30

Accepted: Dec 04, 2017

DOI: https://doi.org/10.2478/acph-2018-0010

Keywordsliver failure, hepatitis B virus, nucleoside analogue, tenofovir, network meta-analysis

© by Xinmin Zhou

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
liver failure, hepatitis B virus, nucleoside analogue, tenofovir, network meta-analysis