<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents, an enormous financial burden is placed on healthcare systems around the world. Therefore, novel approaches to the prevention and treatment of UTIs are needed. Although UPEC may harbour a plethora of virulence factors, type I fimbriae and P pili are two of the most studied adhesive organelles, since the attachment to host cells in the urinary tract is a crucial step towards infection. Design of receptor analogues that competitively bind to UPEC surface adhesins placed at the top of pili organelles led to the development of anti-adhesive drugs that are increasingly recognized as important and promising alternatives to antibiotic treatment of UTIs.</p></abstract>

Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents, an enormous financial burden is placed on healthcare systems around the world. Therefore, novel approaches to the prevention and treatment of UTIs are needed. Although UPEC may harbour a plethora of virulence factors, type I fimbriae and P pili are two of the most studied adhesive organelles, since the attachment to host cells in the urinary tract is a crucial step towards infection. Design of receptor analogues that competitively bind to UPEC surface adhesins placed at the top of pili organelles led to the development of anti-adhesive drugs that are increasingly recognized as important and promising alternatives to antibiotic treatment of UTIs.

Effective anti-adhesives of uropathogenic Escherichia coli

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Effective anti-adhesives of uropathogenic Escherichia coli"}

Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent...

Effective anti-adhesives of uropathogenic Escherichia coli

Published Online: Feb 16, 2018

Page range: 1 - 18

Accepted: Nov 02, 2017

DOI: https://doi.org/10.2478/acph-2018-0004

Keywords
urinary tract infections, type I fimbriae, P pili, mannosides, cranberry, polyphenols

© by Rosana Ribić

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Effective anti-adhesives of uropathogenic Escherichia coli

Published Online: Feb 16, 2018

Page range: 1 - 18

Accepted: Nov 02, 2017

DOI: https://doi.org/10.2478/acph-2018-0004

Keywordsurinary tract infections, type I fimbriae, P pili, mannosides, cranberry, polyphenols

© by Rosana Ribić

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
urinary tract infections, type I fimbriae, P pili, mannosides, cranberry, polyphenols