<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This paper describes the seasonal phytochemical variation and the antimicrobial potential of V. zizanioides roots collected in Brazil. Considering the high levels of chemical constituents and their biological activity in dichloromethane fraction, the plants were grown in different seasons and the respective dichloromethane fractions were analyzed by gas chromatography-mass spectrometry. The antimicrobial activity was evaluated against several pathogenic microorganisms by determining the minimum inhibitory concentration (MIC) using the agar dilution method. Yields of dichloromethane fractions from plants collected in the autumn and spring occurred in a higher proportion than in other seasons. Khusimol (2) was isolated by column chromatography and identified by NMR and CG-MS, along with other sesquiterpenes, including β-vetivenene (1), vetiselinenol (3), isovalencenol (4), vetivenic acid (5), α-vetivone (6) and β-vetivone (7). Some extracts showed promising antimicrobial effects, with MICs ranging from 31.25 to 500 μg mL-1. Kushimol was slightly active against the tested microorganisms.</p></abstract>

This paper describes the seasonal phytochemical variation and the antimicrobial potential of V. zizanioides roots collected in Brazil. Considering the high levels of chemical constituents and their biological activity in dichloromethane fraction, the plants were grown in different seasons and the respective dichloromethane fractions were analyzed by gas chromatography-mass spectrometry. The antimicrobial activity was evaluated against several pathogenic microorganisms by determining the minimum inhibitory concentration (MIC) using the agar dilution method. Yields of dichloromethane fractions from plants collected in the autumn and spring occurred in a higher proportion than in other seasons. Khusimol (2) was isolated by column chromatography and identified by NMR and CG-MS, along with other sesquiterpenes, including β-vetivenene (1), vetiselinenol (3), isovalencenol (4), vetivenic acid (5), α-vetivone (6) and β-vetivone (7). Some extracts showed promising antimicrobial effects, with MICs ranging from 31.25 to 500 μg mL-1. Kushimol was slightly active against the tested microorganisms.

Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots

Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)-Universidade do Vale do Itajaí, 88302-202, Itajaí, SC, Brazil

Universidad Autónoma de Yucatán (UADY) Calle 41 No 421 x 26 y 28 Col. Industrial, C.P. 97150, Mérida Yucatán, Mexico

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

This paper describes the seasonal phytochemical variation and the antimicrobial potential of V. zizanioides roots collected in Brazil. Considering the high...

Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots

Published Online: Dec 20, 2014

Page range: 495 - 501

Accepted: Sep 27, 2014

DOI: https://doi.org/10.2478/acph-2014-0040

Keywords
Vetiveria zizanioides (Poaceae), seasonality, sesquiterpenes, khusimol, antimicrobial activity

© by Valdir Cechinel Filho

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots

Published Online: Dec 20, 2014

Page range: 495 - 501

Accepted: Sep 27, 2014

DOI: https://doi.org/10.2478/acph-2014-0040

KeywordsVetiveria zizanioides (Poaceae), seasonality, sesquiterpenes, khusimol, antimicrobial activity

© by Valdir Cechinel Filho

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Vetiveria zizanioides (Poaceae), seasonality, sesquiterpenes, khusimol, antimicrobial activity