<abstract xmlns="http://www.w3.org/1999/xhtml"><p> During the manufacture of bulk drug midazolam various impurities arised that can be the related products or degradation products. Structures of eight impurities that can arise during the manufacture of bulk drug midazolam were proposed. In the present work, synthesis of these impurities and their characterization by different spectroscopic techniques have been done. HPLC method was developed for the separation of impurities from the bulk drug. The developed method separates midazolam from its eight impurities/degradation products within a run time of 45 min.</p></abstract>

During the manufacture of bulk drug midazolam various impurities arised that can be the related products or degradation products. Structures of eight impurities that can arise during the manufacture of bulk drug midazolam were proposed. In the present work, synthesis of these impurities and their characterization by different spectroscopic techniques have been done. HPLC method was developed for the separation of impurities from the bulk drug. The developed method separates midazolam from its eight impurities/degradation products within a run time of 45 min.

Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC

Department of Pharmacy, Banashtali University, Banashtali, Rajasthan, India

Department of Pharmaceutical Sciences H. N. B. Garhwal University, Srinagar Garhwal, Uttarakhand, India

East Point College of Pharmacy Bidarahalli, Virgonagar Post, Bangalore Karnataka, India

Indian Medicines Pharmaceutical Corporation Ltd, Mohan, Ramnagar, India

Institute of Pharmacy and Emerging Sciences Baddi University of Emerging Science and Technology, Makhnumajra Baddi, Distt. Solan Himachal Pradesh India

Acta Pharmaceutica

During the manufacture of bulk drug midazolam various impurities arised that can be the related products or degradation products. Structures of eight...

Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC

Published Online: Oct 22, 2013

Page range: 385 - 396

DOI: https://doi.org/10.2478/acph-2013-0025

Keywords
midazolam, impurities, degradation products, HPLC method

This content is open access.

Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC

Published Online: Oct 22, 2013

Page range: 385 - 396

DOI: https://doi.org/10.2478/acph-2013-0025

Keywordsmidazolam, impurities, degradation products, HPLC method

This content is open access.

Keywords
midazolam, impurities, degradation products, HPLC method