<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The present work envisages utilisation of biodegradable and biocompatible material from natural sources for the development of controlled release microspheres of metformin hydrochloride (MetH). Natural polysaccharides extracted from Dillenia indica L. (DI), Abelmoschus esculentus L. (AE) and Bora rice flour were used in fabricating controlled release microspheres. The microspheres were prepared by the emulsion solvent diffusion technique with different proportions of natural materials and were studied for entrapment efficiency, particle size, particle shape, surface morphology, drug excipient compatibility, mucoadhesivity and in vitro release properties. The prepared microspheres showed mucoadhesive properties and controlled release of metformin hydrochloride. The study has revealed that natural materials can be used for formulation of controlled release microspheres and will provide ample opportunities for further study</p></abstract>

The present work envisages utilisation of biodegradable and biocompatible material from natural sources for the development of controlled release microspheres of metformin hydrochloride (MetH). Natural polysaccharides extracted from Dillenia indica L. (DI), Abelmoschus esculentus L. (AE) and Bora rice flour were used in fabricating controlled release microspheres. The microspheres were prepared by the emulsion solvent diffusion technique with different proportions of natural materials and were studied for entrapment efficiency, particle size, particle shape, surface morphology, drug excipient compatibility, mucoadhesivity and in vitro release properties. The prepared microspheres showed mucoadhesive properties and controlled release of metformin hydrochloride. The study has revealed that natural materials can be used for formulation of controlled release microspheres and will provide ample opportunities for further study

Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources

Department of Pharmaceutical Sciences Dibrugarh University Dibrugarh-786004, Assam, India

Acta Pharmaceutica

The present work envisages utilisation of biodegradable and biocompatible material from natural sources for the development of controlled release microspheres...

Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources

Published Online: Jul 10, 2013

Page range: 209 - 222

DOI: https://doi.org/10.2478/acph-2013-0019

Keywords
metformin hydrochloride, Dillenia indica, Abelmoschus esculentus, Bora rice, emulsion solvent diffusion technique, mucoadhesive, microspheres

This content is open access.

Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources

Published Online: Jul 10, 2013

Page range: 209 - 222

DOI: https://doi.org/10.2478/acph-2013-0019

Keywordsmetformin hydrochloride, Dillenia indica, Abelmoschus esculentus, Bora rice, emulsion solvent diffusion technique, mucoadhesive, microspheres

This content is open access.

Keywords
metformin hydrochloride, Dillenia indica, Abelmoschus esculentus, Bora rice, emulsion solvent diffusion technique, mucoadhesive, microspheres