<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Direct oral anticoagulants represent a significant group of drugs used in the prevention or treatment of venous thromboembolic events and stroke in patients with atrial fibrillation. Although routine therapy monitoring is not required, there is an increasing evidence that plasma levels may vary between individuals, suggesting the benefit of plasma levels measurement in some situations. Therapeutic drug monitoring is becoming more popular and accessible to the broader population. Introducing microsampling techniques for the quantitative collection of blood samples has arisen nowadays. The volumetric absorptive microsampling approach using a commercially available device such as a Mitra stick overcomes the hematocrit effect present in the dry blood spot technique. This review discusses the possible application of the volumetric absorptive microsampling approach in monitoring direct oral anticoagulant therapy efficacy.</p>
</abstract>

Direct oral anticoagulants represent a significant group of drugs used in the prevention or treatment of venous thromboembolic events and stroke in patients with atrial fibrillation. Although routine therapy monitoring is not required, there is an increasing evidence that plasma levels may vary between individuals, suggesting the benefit of plasma levels measurement in some situations. Therapeutic drug monitoring is becoming more popular and accessible to the broader population. Introducing microsampling techniques for the quantitative collection of blood samples has arisen nowadays. The volumetric absorptive microsampling approach using a commercially available device such as a Mitra stick overcomes the hematocrit effect present in the dry blood spot technique. This review discusses the possible application of the volumetric absorptive microsampling approach in monitoring direct oral anticoagulant therapy efficacy.

Volumetric Absorptive Microsampling Technique in the LC-MS Determination of Direct Oral Anticoagulants

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Direct oral anticoagulants represent a significant group of drugs used in the prevention or treatment of venous thromboembolic events and stroke in patients...

Volumetric Absorptive Microsampling Technique in the LC-MS Determination of Direct Oral Anticoagulants

Published Online: Apr 20, 2023

Page range: 23 - 31

Received: Mar 07, 2023

Accepted: Mar 12, 2023

DOI: https://doi.org/10.2478/acm-2023-0004

Keywords
direct oral anticoagulants, microsampling techniques, therapeutic drug monitoring, volumetric absorptive microsampling

© 2023 Kertys M. et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Volumetric Absorptive Microsampling Technique in the LC-MS Determination of Direct Oral Anticoagulants

Published Online: Apr 20, 2023

Page range: 23 - 31

Received: Mar 07, 2023

Accepted: Mar 12, 2023

DOI: https://doi.org/10.2478/acm-2023-0004

Keywordsdirect oral anticoagulants, microsampling techniques, therapeutic drug monitoring, volumetric absorptive microsampling

© 2023 Kertys M. et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
direct oral anticoagulants, microsampling techniques, therapeutic drug monitoring, volumetric absorptive microsampling